Summary

Buyer: Endo Pharmaceuticals (ENDP) Last Price: 33.97 Market Cap.: 4.53B
Target: Protherics PLC (ADR) (PTIL) Last Price: 14.24 Market Cap.: 3.45B

Lines of Business Summary:

Product Summary:

Overlap & Complementary Sectors

Sector Buyer Target # of Focused Companies
*Healthcare 866
Biopharmaceuticals 322
Veterinary Products and Services   7

- Focused. Denotes that the company is considered focused in this area. In general, Focused Companies draw the majority of their earnings in the sector/product area specified.

- Sector Pure-Plays. Denotes that the company is focused in the selected sector and generates nearly all earnings in the sector/product area specified.

- Sector Participation. Denotes that the company develops products in this line of business.

Sample Products in Similar Lines of Business

Sample Products in Complementary Lines of Business

Buyer (Total: 27)
  • Symmetrel (Amantadine Hydrochloride)
  • Frova (Frovatriptan Succinate)
  • Endo Generics Carbidopa/Levodopa
  • Endo Generics Selegiline Hydrochloride
Target (Total: 7)
  • Angiotensin Vaccine
  • CytoFab
  • Prolarix
  • CroFab [(Crotalidae Polyvalent Immune Fab (Ovine)]
Buyer

n/a

Target
  • Protherics Enfer TSE Diagnostic Kit

Business Relationship Summary:

Top Key Suppliers

Top Key Customers

Buyer (Total: 7)
  • DURECT Corporation (DRRX)
  • Vernalis plc (ADR) (VNLS)
  • United Parcel Service (UPS)
  • SAP AG (ADR) (SAP)
Target (Total: 1)
  • Symbion Health Limited (SYHTY)
Buyer (Total: 1)
  • EpiCept Corporation (EPCT)
Target (Total: 0)

n/a

Key Financial Summary:

Key Metrics

  Buyer Target
Number of Employees 710 214
Revenue Per Employee 1,288,149.0 125,374.4
Total Revenue 228.0 13.2
Total Expenses 138.8 24.4
Other Revenue 0.0 0.0
Cost of Revenue 50.4 6.8
SG&A Expense 64.3 9.3
Research & Development 19.8 8.2
Other Operating Expense 0.0 0.0
Operating Income 89.2 -11.2
Unusual Income 0.0 0.0
LT Debt to Capital 0 12.91
Fwd P/E 21.28 n/a
Fwd P/Rev 4.93 n/a
Book Value 972.4 49.5
Curr Portion of LTD/Cap Lease 0.0 1.2

Key Ratios

  Buyer Target
Gross Margin % 76.75 36.24
Operating Margin % 36.14 -53.83
Quick Ratio 2.16 1.83
Current Ratio 2.49 2.47
Coverage Ratio 0.05 0
Total Assets 1,395.3 113.0
Return on Equity % 22.38 -36
Return on Assets % 15.6 -15.78
Cash+ ST Inv. Per Share 4.57 1.91
Total Debt 0.0 8.6
Total Debt to Equity % 0 17.33
Total Debt to Tangible Equity % 0 28.38
Debt to Asset % 0.00 7.59

Individual Company Summary

Focused

Buyer

Focused (): *Healthcare > Biopharmaceuticals > Pain Management

Target

Focused (): *Healthcare > Biopharmaceuticals

Business Description

Buyer

Endo Pharmaceuticals Holdings Inc. through it's wholly owned subsidiary, Endo Pharmaceuticals Inc. (Endo), is engaged in the sales, marketing, research and development of branded and generic pharmaceutical products primarily in the United States. Its portfolio of branded products includes Lidoderm, Percocet, Percodan, Frova, DepoDur and Zydone. The Company concentrates on generics that have one or more barriers to market entry, such as complex formulation, regulatory or legal challenges or difficulty in raw material sourcing. Its late-stage branded products pipeline includes two filed new drug applications (NDAs), three products in Phase III clinical trials and four products in Phase II clinical trials. During the year ended December 31, 2005, the branded products and the generic portfolio comprised approximately 71% and 29%, respectively, of the Company's net sales.

Target

Protherics PLC is a biopharmaceutical company engaged in the development, manufacture and sale of pharmaceutical products for the treatment of human diseases. The Company's core technology is focused on immunotherapeutics and oncology. Immunotherapeutics encompasses the use of antibodies to combat the effects of disease or poisoning. Protherics PLC has manufacturing facilities in Wales, Australia and Salt Lake City, Utah. On December 7, 2005, the Company licensed CytoFab, its product developed for the treatment of sepsis, to AstraZeneca Ireland Operations, a branch in Ireland of AstraZeneca UK Limited (AstraZeneca).

Product Summary

Sector Buyer Target
*Healthcare
Biopharmaceuticals
Cardiovascular System
The Cardiovascular System Subsector includes therapeutics that treat disorders affecting the heart and blood vessels.
 
Infectious Diseases
The Infectious Diseases Subsector includes therapeutics that treat diseases caused by the invasion and reproduction of microorganisms in the body.
Neurology
The Neurology Subsector includes therapeutics that treat disorders of the central nervous system, including the brain, spinal cord, and nerves.
 
Oncology
The Oncology Subsector includes therapeutics that treat and manage various types of cancer and related complications.
Pain Management
The Pain Management Subsector includes therapeutics that treat and management pain.
 
Respiratory System
The Respiratory System Subsector includes therapeutics that treat disorders affecting both the upper and lower respiratory tract, including the nose, throat, larynx, trachea, bronchi, and lungs.
 
Toxicology
The Toxicology Subsector includes therapeutics that treat harmful effects from exposure to toxic substances; narcotics, nicotine and alcohol withdrawal therapeutics are also included in this sector.
Veterinary Products and Services  
Veterinary Diagnostics
The Veterinary Diganostics Subsector includes companies that manufacture veterinary diagnostics for the detection and monitoring of veterinary diseases.

Target Products:

  • Protherics Enfer TSE Diagnostic Kit
 

- Focused. Denotes that the company is considered focused in this area. In general, Focused Companies draw the majority of their earnings in the sector/product area specified.

- Sector Pure-Plays. Denotes that the company is focused in the selected sector and generates nearly all earnings in the sector/product area specified.

- Sector Participation. Denotes that the company develops products in this line of business.

Product Details

Sector Buyer Target
*Healthcare
Biopharmaceuticals
Cardiovascular System  
Research/Preclinical Stage Products
Therapeutics that are being investigated for the treatment of heart and circulatory system disorders in very early stages of research where no human subject is involved.

Target Products:

  • Angiotensin Vaccine
 
Infectious Diseases
Phase I/Phase II Clinical Stage Products
Therapeutics that are being investigated for the treatment of infectious diseases in early stages of clinical research where human subject is involved.

Target Products:

  • CytoFab
 
Viral  
RNA Viruses  
Orthomyxovirus  
Influenza A  
Viral Uncoating Inhibitors
Therapeutics that treat viral infections of the respiratory tract caused by Influenza A virus by preventing the removal of the protective shield around the viral genome, thus preventing the release of viral DNA into the host.

Buyer Products:

  • Symmetrel (Amantadine Hydrochloride)
 
Neurology  
Neurological Disorders  
Headaches  
Vascular (Migraine)  
Acute Treatments  
Selective Serotonin Receptor Agonists (Triptans)
Therapeutics that treat vascular/migraine headaches by stimulating the receptor that binds with the neurotransmitter, serotonin.

Buyer Products:

  • Frova (Frovatriptan Succinate)
 
Neuromuscular Disorders  
Parkinson`s Disease (PD)  
Adjunctive Treatments  
Dopamine Receptor Agonists
Therapeutics that assist in the treatment of the disorder involving nerve cell loss in portions of the brain that leads to uncontrolled tremors, abnormal posture and speech problems by stimulating dopamine receptors on neurons.

Buyer Products:

  • Endo Generics Carbidopa/Levodopa
 
Monoamine Oxidase (MAO) Inhibitors
Therapeutics that assist in the treatment of the disorder involving nerve cell loss in portions of the brain that leads to uncontrolled tremors, abnormal posture and speech problems by inhibiting the degradation of neurotransmitters.

Buyer Products:

  • Endo Generics Selegiline Hydrochloride
 
Serotonin/Dopamine Reuptake Inhibitors
Therapeutics that treat the disorder involving nerve cell loss in portions of the brain that leads to uncontrolled tremors, abnormal posture and speech problems by blocking the reabsorption of serotonin and dopamine in the brain.

Buyer Products:

  • Symmetrel (Amantadine Hydrochloride)
 
Psychiatric Disorders  
Schizophrenia  
Monoaminergic Antagonists
Therapeutics that treat schizophrenia by blocking the serotonin and dopamine receptors.

Buyer Products:

  • Moban (Molindone Hydrochloride)
 
Oncology
Phase I/Phase II Clinical Stage Products
Therapeutics that are being investigated for the treatment and management of cancer in early stages of clinical research where human subject is involved.

Buyer Products:

  • Rapinyl (Sublingual Fentanyl)

Target Products:

  • Prolarix
Pain Management  
Anesthesia  
General (Systemic)  
Adjunctive  
Opioids
Therapeutics that treat pain by binding to certain nervous system receptors which alters both the perception of pain as well as the emotional response to pain.

Buyer Products:

  • Numorphan (Oxymorphone Hydrochloride)
  • Nubain (Nalbuphine Hydrochloride)
 
Local  
Sodium Channel Blocking Agents
Therapeutics that treat pain by blocking the movement of sodium ions and thus the initiation and conduction of nerve impulses across the neuronal membrane.

Buyer Products:

  • Synera Patch (Lidocaine/Tetracaine)
  • Lidoderm (Lidocaine)
 
Narcotics  
Analgesics/Opioids
Therapeutics that treat pain by binding to certain nervous system receptors which alters the both the perception of pain as well as the emotional response to pain.

Buyer Products:

  • Percocet (Acetaminophen/Oxycodone)
  • Percodan (Aspirin/Oxycodone)
  • Endo Generics Endocet (Acetaminophen/Oxycodone)
  • Zydone (Hydrocodone Bitartrate/Acetaminophen)
  • Endo Generics Aspirin/Oxycodone
 
Opioids
Therapeutics that treat pain by binding to certain nervous system receptors which alter both the perception of pain as well as the emotional response to pain.

Buyer Products:

  • Endo Generics Morphine Sulfate Extended-Release Tablets
  • Opana IR (Oxymorphone Hydrochloride Immediate-Release)
  • Depodur (Morphine Sulfate/Liposome)
  • DUROS Chronogesic (Sufentanil)
  • Numorphan (Oxymorphone Hydrochloride)
  • Opana ER (Oxymorphone Hydrochloride Extended-Release)
  • Nubain (Nalbuphine Hydrochloride)
  • Rapinyl (Sublingual Fentanyl)
  • Oxycodone Hydrochloride ER
 
Non-Narcotics  
Non-Steroidal Anti-Inflammatory Drugs (NSAID)  
Non-Specific Cyclooxygenase Inhibitors (COX Inhibitors)
Therapeutics that treat pain by non-specifically inhibiting the action of cyclooxygenase.

Buyer Products:

  • Ketoprofen Patch
 
Sodium Channel Blocking Agents
Therapeutics that treat pain by blocking the movement of sodium ions and thus the initiation and conduction of nerve impulses across the neuronal membrane.

Buyer Products:

  • Synera Patch (Lidocaine/Tetracaine)
 
Phase I/Phase II Clinical Stage Products
Therapeutics that are being investigated for the treatment of pain in early stages of clinical research where human subject is involved.

Buyer Products:

  • Transdermal Sufentanil Patch
  • LidoPAIN BP
  • Lidoderm (Lidocaine)
 
Respiratory System  
Upper Respiratory Tract Disorders  
Coughs/Colds  
Anticholinergic Agents/Opioids
Therapeutics that treat coughs and colds by relieving pain and fever as well as suppressing cough.

Buyer Products:

  • Hycodan (Hydrocodone Bitartrate/Homatropine Methylbromide)
 
Expectorants/Opioids
Therapeutics that treat coughs and colds by suppressing the cough and helping in the ejection of the mucous.

Buyer Products:

  • Hycotuss (Guaifenesin/Hydrocodone Bitartrate)
 
Toxicology
Animal Poisoning  
Snakes  
Immunoglobulins
Therapeutics that treat snake bites with target specific proteins that neutralize the poison.

Target Products:

  • CroFab [(Crotalidae Polyvalent Immune Fab (Ovine)]
 
Chemical Poisoning  
Digoxin  
Digoxin Binding Agents
Therapeutics that treat toxicity due to ingestion of excessive digoxin by competitively binding to digoxin, making them unavailable for binding at their site of action on cells in the body.

Target Products:

  • DigiFab [Digoxin Immune Fab (Ovine)]
 
Methotrexate  
Carboxypeptidase
Therapeutics that treat methotrexate toxicity by catalyzing its carboxyl groups.

Target Products:

  • Voraxaze
 
Substance Abuse  
Withdrawal  
Narcotics  
Opioid Antagonists
Therapeutics that treat narcotic addiction by blocking the effect of opioids.

Buyer Products:

  • Narcan (Naloxone Hydrocloride)
 
Veterinary Products and Services  
Veterinary Diagnostics
The Veterinary Diganostics Subsector includes companies that manufacture veterinary diagnostics for the detection and monitoring of veterinary diseases.

Target Products:

  • Protherics Enfer TSE Diagnostic Kit
 

- Focused. Denotes that the company is considered focused in this area. In general, Focused Companies draw the majority of their earnings in the sector/product area specified.

- Sector Pure-Plays. Denotes that the company is focused in the selected sector and generates nearly all earnings in the sector/product area specified.

- Sector Participation. Denotes that the company develops products in this line of business.

Relationship Details

Key Competitors

  Name Dir Percent Market Cap. P/E Ratio (TTM) Fwd P/E P/R Ratio (TTM) Fwd P/Rev Price To Tang. Book Value
Buyer
  Pfizer Inc. n/a 197,233.738 18.27 13.50 4.17 4.14 9.26
Johnson & Johnson n/a 188,429.910 17.37 17.41 3.67 3.55 6.86
Abbott Laboratories n/a 74,862.543 24.11 19.57 3.39 3.36 44.96
Tyco International Ltd. n/a 53,228.745 15.99 14.73 1.37 1.31 11.32
Teva Pharmaceutical Industries Ltd (ADR) n/a 26,074.362 1,055.64 15.89 3.97 3.09 -846.57
Elan Corporation, plc (ADR) n/a 6,415.669 n/a -19.55 11.89 10.65 -9.44
Watson Pharmaceuticals, Inc. n/a 2,616.806 42.67 20.81 1.50 1.40 2.49
Alpharma Inc. n/a 1,177.128 7.50 15.65 1.93 1.84 1.68
New River Pharmaceuticals, Inc. n/a 963.193 n/a -55.09 35.91 22.77 963,193.25
Ligand Pharmaceuticals Inc. n/a 755.913 n/a -29.37 3.91 n/a -2.07
Pain Therapeutics, Inc. n/a 387.262 n/a 96.44 18.98 6.59 5.84
Impax Laboratories Inc. n/a 371.378 739.66 6.46 3.30 1.68 6.33
POZEN Inc. n/a 291.769 n/a -12.38 10.51 28.69 11.89
Acura Pharmaceuticals, Inc. n/a 280.406 n/a n/a n/a n/a -32.95
DURECT Corporation n/a 234.723 n/a -9.67 8.26 9.91 7.26
AVANIR Pharmaceuticals n/a 215.078 n/a -3.88 8.35 11.37 6.78
Gentium S.p.A. (ADR) n/a 150.204 n/a n/a 32.11 n/a 8.49
EpiCept Corporation n/a 55.672 n/a n/a 66.44 n/a -4.93
Pharmos Corporation n/a 33.174 n/a -2.53 n/a n/a 0.78
BioDelivery Sciences International, Inc. n/a 31.779 n/a n/a 39.25 n/a -7.91
Purdue Pharma L.P. n/a n/a n/a n/a n/a n/a n/a
Javelin Pharmaceuticals Inc. n/a n/a n/a -9.27 n/a n/a n/a
Boehringer Ingelheim GmbH n/a n/a n/a n/a n/a n/a n/a

- Defined by the Company - Defined by Others

Dependent Suppliers

  Name Dir Percent Market Cap. P/E Ratio (TTM) Fwd P/E P/R Ratio (TTM) Fwd P/Rev Price To Tang. Book Value
Buyer
  DURECT Corporation 26.00% 234.723 n/a -9.67 8.26 9.91 7.26
Vernalis plc (ADR) 22.50% 251.103 n/a n/a 9.70 n/a -21.63
United Parcel Service n/a 76,838.756 19.21 18.42 1.68 1.63 5.59
SAP AG (ADR) n/a 58,670.780 28.15 26.37 5.10 4.97 11.64
Noven Pharmaceuticals, Inc. n/a 537.299 53.42 35.38 10.54 8.45 3.84
Penwest Pharmaceuticals n/a 456.947 n/a -13.10 76.48 75.97 n/a
SkyePharma PLC (ADR) n/a 350.500 n/a n/a 3.00 n/a -2.89
Target
  Symbion Health Limited n/a 1,495.227 24.73 n/a 0.51 n/a 5.19

- Defined by the Company - Defined by Others

Key Customers

  Name Dir Percent Market Cap. P/E Ratio (TTM) Fwd P/E P/R Ratio (TTM) Fwd P/Rev Price To Tang. Book Value
Buyer
  EpiCept Corporation n/a 55.672 n/a n/a 66.44 n/a -4.93

- Defined by the Company - Defined by Others

Key Partners

  Name Dir Percent Market Cap. P/E Ratio (TTM) Fwd P/E P/R Ratio (TTM) Fwd P/Rev Price To Tang. Book Value
Buyer
  Novartis AG (ADR) n/a 134,289.621 23.59 18.57 3.84 3.66 3.61
United Parcel Service n/a 76,838.756 19.21 18.42 1.68 1.63 5.59
Tyco International Ltd. n/a 53,228.745 15.99 14.73 1.37 1.31 11.32
inVentiv Health Inc. n/a 842.790 14.77 21.66 1.28 1.17 -20.21
Noven Pharmaceuticals, Inc. n/a 537.299 53.42 35.38 10.54 8.45 3.84
Penwest Pharmaceuticals n/a 456.947 n/a -13.10 76.48 75.97 n/a
SkyePharma PLC (ADR) n/a 350.500 n/a n/a 3.00 n/a -2.89
Vernalis plc (ADR) n/a 251.103 n/a n/a 9.70 n/a -21.63
DURECT Corporation n/a 234.723 n/a -9.67 8.26 9.91 7.26
EpiCept Corporation n/a 55.672 n/a n/a 66.44 n/a -4.93
ProEthic Pharmaceuticals, Inc. n/a n/a n/a n/a n/a n/a n/a
Teikoku Seiyaku Pharmaceuticals n/a n/a n/a n/a n/a n/a n/a
Hind Healthcare Inc. n/a n/a n/a n/a n/a n/a n/a
Orexo AB n/a n/a n/a n/a n/a n/a n/a
ZARS, Inc. n/a n/a n/a n/a n/a n/a n/a
Target
  AstraZeneca PLC (ADR) n/a 98,768.323 18.17 16.47 3.97 3.83 9.59
Altana AG (ADR) n/a 7,780.441 13.43 13.22 1.75 n/a 4.21
Symbion Health Limited n/a 1,495.227 24.73 n/a 0.51 n/a 5.19
Beacon Pharmaceuticals Ltd. n/a n/a n/a n/a n/a n/a n/a
Cancer Research UK n/a n/a n/a n/a n/a n/a n/a
Enfer Scientific Ltd. n/a n/a n/a n/a n/a n/a n/a
Swedish Orphan AB n/a n/a n/a n/a n/a n/a n/a

- Defined by the Company - Defined by Others

Financials

  Buyer Target Combined Entity
Income Statement
Operating Items
Revenue 919.1 33.3 952.4
Other Revenue 0.0 0.0 0.0
Total Revenue 919.1 33.3 952.4
Cost of Revenue 213.7 21.2 234.9
SG&A Expense 266.0 17.3 283.3
Depreciation & Amortization 16.5 0.0 16.5
Research & Development 85.3 12.7 97.9
Interest Expense 0.0 0.0 0.0
Other Operating Expense 0.0 0.0 0.0
Unusual Expense (Income) 5.5 0.0 5.5
Total Expenses 586.9 51.2 638.1
Operating Income 332.2 -17.9 314.2
Non Operating Items
Interest Expense (Inc.), Net Non-Oprtng 17.2 -0.1 17.2
Other, Net 0.0 0.0 0.0
Income Before Taxes 349.4 -18.0 331.4
Income Taxes 131.8 -0.1 131.7
Income After Taxes 217.6 -17.8 199.8
Net Income - Excl. Xord. Items 217.6 -17.8 199.8
Net Income - Incl. Xord. Items 217.6 -17.8 199.8
Income Avail. to Common 217.6 -17.8 199.8
Share Items
Basic Avg. Shares Outstanding 133.1 25.1 158.1
Basic EPS - Excl. Xord. Items 1.64 n/a 1.26
Basic EPS - Incl. Xord. Items 1.64 n/a 1.26
Full Dilution Adjustment 0.0 0.0 0.0
Fully Diluted Shares Outstanding 133.9 25.1 159.0
F.D. EPS - Excl. Xord. Items 1.62 n/a 1.26
F.D. EPS - Incl. Xord. Items 1.62 n/a 1.26
Balance Sheet
Assets
Cash and Equivalents 612.7 47.8 660.5
Accounts Receivable 259.7 9.8 269.5
Inventory 61.8 20.5 82.3
Prepayments and Advances 7.8 0.0 7.8
Other Current Assets 63.5 0.0 63.5
Current Assets 1,005.5 78.1 1,083.6
Accum D&A 0.0 0.0 0.0
PPE, Net 34.7 15.2 49.9
Goodwill & Intangibles 295.0 19.3 314.3
Note Receivable 50.9 0.0 50.9
Other Assets 0.0 0.0 0.0
Other LT Assets 9.3 0.4 9.6
Total Assets 1,395.3 113.0 1,508.3
Liabilities
Accounts Payable 106.8 29.6 136.3
Payable/Accrued 0.0 0.0 0.0
Accrued Expenses 178.2 0.0 178.2
ST Debt 0.0 0.1 0.1
Curr Port of LTD & Cap Lease Oblg 0.0 1.2 1.2
Other (Current) Liabilities 118.5 0.8 119.3
Current Liab. 403.5 31.6 435.1
LT Debt 0.0 5.1 5.1
Capitalized Lease Obligations 0.0 2.3 2.3
Total LT Debt 0.0 7.3 7.3
Deferred Taxes 16.6 0.0 16.6
Other LT Liab. 2.8 24.6 27.4
Total Liabilities 422.8 63.5 486.3
Shareholders Equity
Common Stock 1.3 9.7 11.1
Additional Paid in Capital 671.3 163.1 834.4
Retained Earnings 299.2 -122.9 176.2
Other Equity 0.6 -0.4 0.2
Total Equity 972.4 49.5 1,022.0
Total Liab. & Equity 1,395.3 113.0 1,508.3
Shares Outstanding 133.1 25.9 159.0
Cash Flow
Operating Cash Flow
CF Net Income 217.6 -17.9 199.7
CF Depreciation 16.5 2.6 19.1
CF Amortization 0.0 0.2 0.2
CF Deferred Taxes -17.1 0.0 -17.1
Other Non-Cash Items 256.5 1.6 258.1
Change in Working Capital -12.9 37.1 24.1
Total Cash From Operating Activities 460.5 23.6 484.1
Investing Cash Flow (not calculated)
Capital Expenditures -22.9 -3.7 -26.6
Other Investing Cash Flows -20.6 1.3 -19.3
Total Cash From Investing Activities -43.5 -2.4 -45.9
Financing Cash Flow (not calculated)
Dividends Paid 0.0 0.0 0.0
Purchase Or Sale of Stock 10.3 15.1 25.4
Purchase and Retirement of Debt -2.7 -1.1 -3.8
Other Financing Cash Flow -88.2 -0.7 -89.0
Total Cash From Financing Activities -80.6 13.0 -67.7
Exchange Rate Effects 0.0 0.0 0.0
Net Change in Cash 336.4 34.2 370.6
Cash Taxes Paid 0.4 0.1 0.5
Cash Interest Paid 1.1 0.7 1.8