Summary

Other Scenarios:

Buyer: Celgene Corporation (CELG) Last Price: 54.67 Market Cap.: 25.05B
Target: Barr Pharmaceuticals, Inc. (BRL) Last Price: 66.99 Market Cap.: 7.33B

Lines of Business Summary:

Product Summary:

Overlap & Complementary Sectors

Sector Buyer Target # of Focused Companies
Healthcare 847
Biopharmaceuticals 369
Healthcare Services   142
Medical Devices 225

- Focused. Denotes that the company is considered focused in this area. In general, Focused Companies draw the majority of their earnings in the sector/product area specified.

- Sector Pure-Plays. Denotes that the company is focused in the selected sector and generates nearly all earnings in the sector/product area specified.

- Sector Participation. Denotes that the company develops products in this line of business.

Sample Products in Similar Lines of Business

Sample Products in Complementary Lines of Business

Buyer (Total: 29)
  • Pharmion Innohep (Tinzaparin Sodium)
  • PDA001 (Human Placenta-derived Stem Cells)
  • Pharmion Oral Azacitidine
  • CC-11006
Target (Total: 184)
  • Hydroxyzine Pamoate
  • Pliva Cyproheptadine HCl
  • Pliva Ketorolac Tromethamine
  • Diphenhydramine Hydrochloride
Buyer
  • LifebankUSA Placental And Cord Blood Stem Cell Bank
  • Biovance
  • Acelagraft Human Amnioyic Membrane Allograft
  • Human Placental Derived Stem Cells (HPDSC)
Target
  • Duramed AmniScreen Home Detection Liner Kit
  • ViaSpan (Belzer UW)
  • ParaGard T 380A

Business Relationship Summary:

Top Key Suppliers

Top Key Customers

Buyer (Total: 8)
  • GPC Biotech AG (ADR) (GPCB)
  • Array BioPharma Inc. (ARRY)
  • GlaxoSmithKline plc (ADR) (GSK)
  • Siegfried Ltd.
Target (Total: 7)
  • Bayer AG (ADR) (BAYRY)
  • Teva Pharmaceutical Industries Ltd (ADR) (TEVA)
  • Cephalon, Inc. (CEPH)
  • Watson Pharmaceuticals, Inc. (WPI)
Buyer (Total: 6)
  • Cardinal Health, Inc. (CAH)
  • McKesson Corporation (MCK)
  • CVS Caremark Corporation (CVS)
  • AmerisourceBergen Corp. (ABC)
Target (Total: 11)
  • McKesson Corporation (MCK)
  • Cardinal Health, Inc. (CAH)
  • Abbott Laboratories (ABT)
  • CVS Caremark Corporation (CVS)

Key Financial Summary:

Key Metrics

  Buyer Target
Number of Employees 1,685 8,900
Revenue Per Employee 1,406,137.0 332,145.9
Total Revenue 592.5 737.0
Total Expenses 432.9 645.0
Other Revenue 0.0 42.0
Cost of Revenue 70.5 342.0
SG&A Expense 168.6 234.0
Research & Development 160.9 69.0
Other Operating Expense 0.0 0.0
Operating Income 159.6 92.0
Unusual Income 0.0 0.0
LT Debt to Capital 0 45.32
Fwd P/E 38.64 22.95
Fwd P/Rev 11.03 2.60
Book Value 3,588.4 2,069.0
Curr Portion of LTD/Cap Lease 0.0 231.0

Individual Company Summary

Focused

Buyer

Focused (): Healthcare > Biopharmaceuticals > Oncology

Target

Focused (): Healthcare > Biopharmaceuticals

Business Description

Buyer

Celgene Corporation is an integrated biopharmaceutical company. The Company is primarily engaged in the discovery, development and commercialization of therapies designed to treat cancer and immune-inflammatory-related diseases. The Company?s lead product is REVLIMID (lenalidomide) and THALOMID. REVLIMID was approved by the United States Food and Drug Administration (FDA), the European Commission, Swiss Agency for Therapeutic Products and Australian Therapeutic Goods Administration, for treatment in combination with dexamethasone for multiple myeloma patients who have received at least one prior therapy. THALOMID was approved by the FDA for treatment in combination with dexamethasone of patients with diagnosed multiple myeloma and is also approved for the treatment and suppression of cutaneous manifestations of erythema nodosum leprosum, an inflammatory complication of leprosy. In March 2008, Celgene Corporation completed the acquisition of Pharmion Corporation.

Target

Barr Pharmaceuticals, Inc. (Barr) is a holding company. Through its subsidiaries, the Company operates as a global specialty pharmaceutical company with operations in more than 30 countries. Through its principal subsidiaries, Barr Laboratories, Inc., Duramed Pharmaceuticals, Inc. (Duramed) and PLIVA d.d. (PLIVA), the Company is engaged in the development, manufacture and marketing of generic and proprietary pharmaceuticals. Barr is also involved in the development of generic biologic products. The Company operates in two business segments: generic pharmaceuticals and proprietary pharmaceuticals. Barr?s generic product portfolio includes solid oral dosage forms, injectables, liquids and cream/ointment products. It markets and sells generic pharmaceutical products in the United States, Europe and certain other countries in the rest of the world (ROW). The Company?s proprietary product portfolio and pipeline is largely concentrated in the area of female healthcare. It markets and sells p

Deal Summary

Key Ratios

  Buyer Target
Gross Margin % 88.44 53.58
Operating Margin % -58.41 13.07
Quick Ratio 6.08 1.82
Current Ratio 6.74 2.64
Coverage Ratio -0.09 -0.27
Total Assets 4,357.4 4,769.0
Return on Equity % -36.48 7.3
Return on Assets % -30.04 3.17
Cash+ ST Inv. Per Share 5.23 5.42
Total Debt 0.0 1,946.0
Total Debt to Equity % 0 94.06
Total Debt to Tangible Equity % 0 460.05
Debt to Asset % 0.00 40.81

Product Summary

Sector Buyer Target
Healthcare
Biopharmaceuticals
Allergies
The Allergies Subsector includes therapeutics that treat exaggerated immune reaction induced by exposure to a foreign substance.
 
Cardiovascular System
The Cardiovascular System Subsector includes therapeutics that treat disorders affecting the heart and blood vessels.
Dermatology
The Dermatology Subsector includes therapeutics that treat disorders affecting the skin.
 
Digestive System
The Digestive System Subsector includes therapeutics that treat disorders affecting the digestive system.
Endocrinology/Metabolism
The Endocrinology/Metabolism Subsector includes therapeutics that treat metabolic disorders and conditions resulting from the dysfunction of hormone secreting glands.
 
Hematology
The Hematology Subsector includes therapeutics that treat blood-based diseases and disorders.
Immunology
The Immunology Subsector includes therapeutics that treat disorders affecting the immune system.
Infectious Diseases
The Infectious Diseases Subsector includes therapeutics that treat diseases caused by the invasion and reproduction of microorganisms in the body.
Musculoskeletal System
The Musculoskeletal System Subsector includes therapeutics that treat disorders of the bones, joints, ligaments, tendons, and soft tissue involved with them.
Neurology
The Neurology Subsector includes therapeutics that treat disorders of the central nervous system, including the brain, spinal cord, and nerves.
Obstetrics/Gynecology
The Obstetrics/Gynecology Subsector includes therapeutics that treat female genital disorders, pregnancy, and childbirth.
 
Oncology
The Oncology Subsector includes therapeutics that treat and manage various types of cancer and related complications.
Ophthalmology
The Ophthalmology Subsector includes therapeutics that treat eye disorders, infections, inflammations and irritations.
 
Pain Management
The Pain Management Subsector includes therapeutics that treat and management pain.
 
Respiratory System
The Respiratory System Subsector includes therapeutics that treat disorders affecting both the upper and lower respiratory tract, including the nose, throat, larynx, trachea, bronchi, and lungs.
 
Surgery
The Surgery Subsector includes therapeutics that treat complications associated with surgical procedures.
Toxicology
The Toxicology Subsector includes therapeutics that treat harmful effects from exposure to toxic substances; narcotics, nicotine and alcohol withdrawal therapeutics are also included in this sector.
 
Transplantation
The Transplantation Subsectors includes therapeutics that treat rejection and infection associated with tissue transplantation into the human body.
 
Urology
The Urology Subsector includes therapeutics that treat diseases of the kidney, urinary tract, bladder, and the male reproductive system.
 
Weight Management
The Weight Management Subsectors includes herapeutics that treat and manage weight disorders.
 
Healthcare Services  
Support Services
The Support Services Subsector is comprised of companies that provide non-medical services for managing, enhancing, facilitating, and enabling the healthcare delivery process.
 
Medical Devices
Cardiology
The Cardiology Subsector includes medical devices that diagnose, monitor, and treat diseases affecting the heart and proximal blood vessels. Common devices include vital sign monitors, cardiac defibrillators, pacemakers, and other surgical equipment.
 
Clinical Diagnostics
The Clinical Diagnostics Subsector includes medical devices that analyze human body specimens within a medical setting. These devices, including equipment, biological and chemical reagents are primarily used for the diagnosis of diseases.
 
General Surgery
The General Surgery Subsector includes medical devices that perform general, non-specialty surgeries; these devices are often general in scope and are used in procedures involving various parts of the body.
 
Obstetrics/Gynecology
The Obstetrics/Gynecology Subsector includes medical devices that diagnose and treat female reproductive diseases; devices used to care for women during pregnancy, childbirth, and the post-partum period are also included in this sector.
 
Transfusion Medicine
The Transfusion Medicine Subsector includes medical devices and accessories that prepare or implement blood transfusion.
 

- Focused. Denotes that the company is considered focused in this area. In general, Focused Companies draw the majority of their earnings in the sector/product area specified.

- Sector Pure-Plays. Denotes that the company is focused in the selected sector and generates nearly all earnings in the sector/product area specified.

- Sector Participation. Denotes that the company develops products in this line of business.

Product Details

Sector Buyer Target
Healthcare
Biopharmaceuticals
Allergies  
Dermatology  
Antihistamines
Products that inhibit inflammation by blocking the action of histamines on tissues.

Target Products:

  • Hydroxyzine Pamoate
 
Antihistamines/Antiserotonins
Therapeutics that inhibit the inflammation by blocking the action of histamines and serotonins on tissues.

Target Products:

  • Pliva Cyproheptadine HCl
 
Ophthalmology  
Antihistamines/Antiserotonins
Therapeutics that inhibit inflammation by blocking the action of histamines and serotonins on tissues.

Target Products:

  • Pliva Cyproheptadine HCl
 
Non-Steroidal Anti-Inflammatory Drugs (NSAID)  
Non-Specific Cyclooxygenase Inhibitors (COX Inhibitors)
Therapeutics that counteract or suppress inflammation preventingcyclooxygenase activity.

Target Products:

  • Pliva Ketorolac Tromethamine
 
Systemic  
Anaphylactic Shock  
Adjunctive Treatments  
Antihistamines/Antiserotonins
Therapeutics that assist the primary treatment of a life-threatening systemic allergic reaction resulting from secondary or subsequent exposure to a foreign substance by blocking the action of histamines and serotonins on tissues.

Target Products:

  • Pliva Cyproheptadine HCl
 
Upper Respiratory  
Antihistamines
Therapeutics that inhibit the inflammation by blocking the action of histamines on tissues.

Target Products:

  • Diphenhydramine Hydrochloride
  • Fexofenadine Hydrochloride (12 Hours Extended Release)
  • Levocetirizine Dihydrochloride
  • Fexofenadine Hydrochloride
 
Antihistamines/Antiserotonins
Therapeutics that inhibit inflammation by blocking the action of histamines and serotonins on tissues.

Target Products:

  • Pliva Cyproheptadine HCl
 
Antihistamines/Decongestants
Therapeutics that block the inflammatory action of histamines and relieve or prevent coughs.

Target Products:

  • Fexofenadine/Pseudoephedrine
 
Steroidal Anti-Inflammatory Drugs (SAID)
Therapeutics that counteract or suppress inflammation using a steroidal compound.

Target Products:

  • Triamcinolone Acetonide Nasal Spray
 
Cardiovascular System
Heart Disorders  
Angina  
Beta Adrenergic Receptor Blocking Agents (Beta Blockers)
Therapeutics that treat chest pains by inhibiting stimulation of beta adrenergic receptors of the heart muscle.

Target Products:

  • Pliva Propranolol Hydrochloride
 
Arrhythmia  
Beta Adrenergic Receptor Blocking Agents (Beta Blockers)
Therapeutics that treat abnormal rhythm of the heart beat by inhibiting the stimulation of beta adrenergic receptors of the heart muscle.

Target Products:

  • Pliva Propranolol Hydrochloride
 
Sodium Channel Blocking Agents
Therapeutics that treat abnormal rhythm of the heart by preventing the entry of sodium into heart muscle cells.

Target Products:

  • Flecainide Acetate
  • Pliva Propafenone HCl
 
Sodium Channel Blocking Agents/Potassium Channel Blocking Agents
Therapeutics that treat abnormal rhythm of the heart by preventing the entry of sodium and potassium into heart muscle cells.

Target Products:

  • Amiodarone Hydrochloride
 
Heart Failure (HF)  
Complications  
Edema  
Loop Diuretic Agents
Therapeutics that treat the excessive accumulation of fluids by increasing the excretion of sodium, potassium, chloride ions, and water in urine.

Target Products:

  • Torsemide
 
Potassium Sparing Diuretic Agents/Thiazide Diuretic Agents
Therapeutics that treat the accumulation of fluid by increasing the excretion of water and sodium, but not potassium in urine.

Target Products:

  • Triamterene/Hydrochlorothiazide
  • Amiloride Hydrochloride/Hydrochlorothiazide
 
Thiazide Diuretic Agents
Therapeutics that treat the accumulation of fluid by increasing the excretion of sodium, potassium ions, and water in urine.

Target Products:

  • Pliva Chlorthalidone
 
Myocardial Infarction (MI)  
Beta Adrenergic Receptor Blocking Agents (Beta Blockers)
Therapeutics that treat irreversible damage to the heart muscle by blocking the beta adrenergic receptors of the heart muscle.

Target Products:

  • Pliva Propranolol Hydrochloride
 
Free Fatty Acid Inhibitors
Therapeutics that treat irreversible damage to the heart muscle by inhibiting the release of fatty acids from adipose tissue.

Target Products:

  • Niaspan (Niacin)
 
HMG CoA Reductase Inhibitors (Statins)
Therapeutics that treat irreversible damage to the heart muscle by preventing the synthesis of cholesterol.

Target Products:

  • Pravastatin Sodium
 
Vascular Disorders
Aneurysms  
Hemorrhage  
Calcium Channel Blocking Agents
Therapeutics that treat bleeding from aneurysms by blocking the flow of calcium ions from the blood vessel wall.

Target Products:

  • Nimodipine
 
Atherosclerosis  
Free Fatty Acid Inhibitors
Therapeutics that treat the narrowing or hardening of arteries by inhibiting the release of fatty acids from adipose tissue.

Target Products:

  • Niaspan (Niacin)
 
HMG CoA Reductase Inhibitors (Statins)
Therapeutics that treat the narrowing or hardening of the arteries by preventing the synthesis of cholesterol.

Target Products:

  • Pravastatin Sodium
 
Deep Vein Thrombosis (DVT)
Anticoagulating Agents (Anticoagulants)
Thrombin Inhibitors
Therapeutics that prevent or treat clots in blood vessels by preventing blood clots from forming.

Buyer Products:

  • Pharmion Innohep (Tinzaparin Sodium)

Target Products:

  • Warfarin Sodium
Hypertension  
Alpha Adrenergic Receptor Blocking Agents (Alpha Blockers)
Therapeutics that treat high blood pressure by blocking alpha adrenergic receptors of the heart muscle.

Target Products:

  • Pliva Doxazosin Mesylate
 
Beta Adrenergic Receptor Blocking Agents (Beta Blockers)
Therapeutics that treat high blood pressure by blocking the beta adrenergic receptors of the heart muscle.

Target Products:

  • Duramed Zebeta (Bisoprolol Fumarate)
  • Pliva Propranolol Hydrochloride
 
Beta Receptor Blocking Agents (Beta Blockers)/Thiazide Diuretic Agents
Therapeutics that treat high blood pressure by blocking the beta adrenergic receptors of the heart muscle and increasing the excretion of sodium ions, potassium ions, and water through urine.

Target Products:

  • Duramed Ziac (Bisoprolol Fumarate/Hydrochlorothiazide)
  • Pliva Propranolol Hydrochloride/Hydrochlorothiazide
 
Loop Diuretic Agents
Therapeutics that treat high blood pressure by increasing the excretion of sodium, potassium, chloride ions, and water in urine.

Target Products:

  • Torsemide
 
Potassium Sparing Diuretic Agents/Thiazide Diuretic Agents
Therapeutics that treat high blood pressure by increasing the excretion of water and sodium, but not potassium in urine.

Target Products:

  • Triamterene/Hydrochlorothiazide
  • Amiloride Hydrochloride/Hydrochlorothiazide
 
Thiazide Diuretic Agents
Therapeutics that treat high blood pressure by increasing the excretion of sodium, potassium ions, and water in urine.

Target Products:

  • Pliva Chlorthalidone
 
Vasodilatory Agents
Therapeutics that treat high blood pressure by causing relaxation of the blood vessels.

Target Products:

  • Pliva Hydralazine
 
Peripheral Vascular Disease  
Blood Viscosity Reducing Agents
Therapeutics that treat arterial obstruction outside of the heart by altering the flow of red blood cells.

Target Products:

  • Pliva Pentoxifylline
 
Free Fatty Acid Inhibitors/HMG CoA Reductase Inhibitors (Statins)
Therapeutics that treat arterial obstruction outside of the heart by inhibiting the release of fatty acids from adipose tissue and blocking cholesterol synthesis by binding a key enzyme in the synthesis process.

Target Products:

  • Advicor (Niacin/Lovastatin)
 
Thromboembolism
Anticoagulating Agents (Anticoagulants)
Platelet Aggregation Inhibitors  
Phosphodiesterase Inhibitors
Therapeutics that treat the obstruction of a blood vessel by preventing platelets from clumping together.

Target Products:

  • Dipyridamole
 
Thrombin Inhibitors
Therapeutics that treat the obstruction of a blood vessel by preventing blood clots from forming.

Buyer Products:

  • Pharmion Innohep (Tinzaparin Sodium)

Target Products:

  • Warfarin Sodium
Tremors  
Beta Adrenergic Receptor Blocking Agents (Beta Blockers)
Therapeutics that prevent or treat involuntary trembling by blocking the beta adrenergic receptors in muscle tissue.

Target Products:

  • Pliva Propranolol Hydrochloride
 
Dermatology  
Acne  
Vulgaris  
Antibacterial Agents  
Macrolides
Therapeutics that treat acne vulgaris caused by bacterial infection by inhibiting RNA-dependent bacterial protein synthesis.

Target Products:

  • Erythromycin
 
Tetracyclines
Therapeutics that treat acne caused by bacterial infections by inhibiting protein synthesis and also causing alterations in cytoplasmic membranes.

Target Products:

  • Tetracycline Hydrochloride
 
Retinoids/Vitamin A Analogs
Therapeutics that treat acne by helping in cell differentiation as well as prevent cell proliferation.

Target Products:

  • Claravis (Isotretinoin)
 
Lesion/Scaling Disorders  
Chronic Urticaria  
Antihistamines
Therapeutics that treat allergic skin conditions by blocking the action of histamines.

Target Products:

  • Fexofenadine Hydrochloride (12 Hours Extended Release)
  • Fexofenadine Hydrochloride
  • Levocetirizine Dihydrochloride
 
Pruritus  
Antihistamines
Therapeutics that inhibit inflammation by blocking the action of histamines on tissues.

Target Products:

  • Hydroxyzine Pamoate
 
Psoriasis  
Dihydrofolate Reductase Inhibitors
Therapeutics that treat a slow growing, chronic inflammatory skin disorder characterized by dry, scaling patches by inhibiting an enzyme needed for the synthesis of DNA.

Target Products:

  • Trexall (Methotrexate)
  • Methotrexate Sodium
 
Immunosuppressants
Therapeutics that treat a slow growing, chronic inflammatory skin disorder characterized by dry, scaling patches by suppressing the immune system.

Target Products:

  • Pliva Cyclosporine
 
Digestive System
Gastrointestinal Tract Disorders  
Gastroduodenal Disorders  
Peptic Ulcers  
Duodenal  
H2 Receptor Antagonists
Therapeutics that treat peptic ulcers by inhibiting the actions of receptors responsible for triggering acid release into the stomach.

Target Products:

  • Pliva Cimetidine
 
Proton Pump Inhibitors
Therapeutics that treat peptic ulcers by inhibiting the membrane protein involved in the final steps of triggering acid release into the stomach.

Target Products:

  • Lansoprazole Delayed-Release
 
Gastric  
H2 Receptor Antagonists
Therapeutics that treat peptic ulcers by inhibiting the actions of receptors responsible for triggering acid release into the stomach.

Target Products:

  • Pliva Cimetidine
 
Zollinger-Ellison Syndrome  
Proton Pump Inhibitors
Therapeutics that treat ulcers by inhibiting the membrane protein involved in the final steps of triggering acid release into the stomach.

Target Products:

  • Lansoprazole Delayed-Release
 
Gastroesophageal Disorders  
Acid Indigestion/Heartburn  
H2 Receptor Antagonists
Therapeutics that treat indigestion by blocking the action of histamine at the H2 receptors.

Target Products:

  • Pliva Cimetidine
 
Erosive Esophagitis  
Proton Pump Inhibitors
Therapeutics that treat Erosive Esophagus by inhibiting the actions of receptors responsible for triggering acid release into the stomach.

Target Products:

  • Lansoprazole Delayed-Release
 
Gastroesophageal Reflux Disease (GERD)  
Dopamine Receptor Blocking Agents
Therapeutics that treat Gastroesophageal Reflux Disease (GERD) by blocking dopamine receptor and stimulating gastrointestinal movement without stimulating secretions from the pancreas, stomach or gall bladder.

Target Products:

  • Pliva Metoclopramide Hydrochloride
 
H2 Receptor Antagonists
Therapeutics that treat Gastroesophageal Reflux Disease by inhibiting the actions of receptors responsible for triggering acid release into the stomach.

Target Products:

  • Pliva Cimetidine
 
Proton Pump Inhibitors
Therapeutics that treat Gastroesophageal Reflux Disease by inhibiting the membrane protein involved in the final steps of triggering acid release into the stomach.

Target Products:

  • Lansoprazole Delayed-Release
 
Gastroparesis  
Dopamine Receptor Blocking Agents
Therapeutics that treat gastroparesis by blocking the action of dopamine.

Target Products:

  • Pliva Metoclopramide Hydrochloride
 
Nausea/Vomiting  
Antihistamines
Therapeutics that inhibit inflammation by blocking the action of histamines on tissues.

Target Products:

  • Pliva Hydroxyzine Hydrochloride
 
Dopamine Receptor Blocking Agents
Therapeutics that treat or prevent nausea and vomiting by blocking the action of dopamine.

Target Products:

  • Pliva Metoclopramide Hydrochloride
  • Prochlorperazine Maleate
 
Serotonin Receptor Antagonists
Therapeutics that treat nausea and vomiting by blocking the serotonin receptors.

Target Products:

  • Ondansetron Hydrochloride
  • Granisetron Hydrochloride
 
Intestinal Disorders  
Intestinal Intubation  
Dopamine Receptor Blocking Agents
Therapeutics that cause bowel evacuation prior to intubation by blocking the action of dopamine.

Target Products:

  • Pliva Metoclopramide Hydrochloride
 
Liver Disorders  
Cirrhosis  
Complications  
Edema  
Loop Diuretic Agents
Therapeutics that prevent edema by excretion of sodium, potassium, chloride ions, and water in urine.

Target Products:

  • Torsemide
 
Potassium Sparing Diuretic Agents/Thiazide Diuretic Agents
Therapeutics that treat the accumulation of abnormally large amounts of fluid in subcutaneous tissue by increasing the excretion of sodium and water, but not potassium in urine.

Target Products:

  • Triamterene/Hydrochlorothiazide
 
Research/Preclinical Stage Products
Therapeutics that are being investigated for the treatment of digestive disorders in very early stages of research where no human subject is involved.

Buyer Products:

  • PDA001 (Human Placenta-derived Stem Cells)
 
Endocrinology/Metabolism  
Adrenal Gland Disorders  
Adrenocortical Insufficiency  
Synthetic Adrenocortical Steroids
Therapeutics that treat Adrenocortical Insufficiency by acting on the distal tubules of the kidney to enhance the reabsorption of sodium ions and to increase the urinary excretion of both potassium and hydrogen ions.

Target Products:

  • Fludrocortisone Acetate
 
Diabetes  
Induced Complications  
Central Diabetes Insipidus  
Antidiuretic Agents
Therapeutics that treat prevent the lose of water in the urine.

Target Products:

  • Desmopressin Acetate
 
Non-Insulin Dependent Diabetes Mellitus (NIDDM)/Type 2 Diabetes  
Biguanides
Therapeutics that treat abnormally high blood glucose levels by decreasing the production of glucose in the liver, decreasing intestinal absorption of glucose and increasing peripheral uptake and utilization of glucose.

Target Products:

  • Metformin Hydrochloride
  • Metformin Hydrochloride Extended-Release
 
Biguanides/Insulin Stimulating Agents
Therapeutics that control high blood sugar by stimulating the release of insulin as well as decreasing the production of glucose in the liver.

Target Products:

  • Metformin Hydrochloride/Glipizide
 
Insulin Stimulating Agents (Sulfonylureas)
Therapeutics that treat non-insulin dependent diabetes by stimulating the secretion of insulin.

Target Products:

  • Pliva Chlorpropamide
 
General Hormone Treatments  
Estrogens
Therapeutics that treat hormonal disorders by providing estrogen.

Target Products:

  • Estradiol
  • Duramed Enjuvia (Synthetic Conjugated Estrogens)
  • Estropipate
  • Duramed Cenestin (Synthetic Conjugated Estrogens, A)
 
Prednisolones
Therapeutics that treat inflammation by preventing the accumulation of inflammatory cells, like macrophages and leukocytes to the inflammation sites.

Target Products:

  • Methylprednisolone
 
Intermediary Metabolism Disorders  
Gout  
Gouty Arthritis  
Urate Resorption Inhibitors
Therapeutics that treat gouty arthritis by preventing the active reabsorption of urate at the renal tubule thus increasing the excretion of urinary acid and lowering serum concentrations of urate.

Target Products:

  • Sulfinpyrazone
 
Hyperuricemia  
Urate Resorption Inhibitors
Therapeutics that inhibit the resorption of urate from the kidneys.

Target Products:

  • Sulfinpyrazone
 
Hypercholesterolemia  
Free Fatty Acid Inhibitors
Therapeutics that treat the abnormally high concentrations of cholesterol by inhibiting the release of fatty acids from adipose tissue.

Target Products:

  • Niaspan (Niacin)
 
Free Fatty Acid Inhibitors/HMG CoA Reductase Inhibitors (Statins)
Therapeutics that treat elevated cholesterol by inhibiting the release of fatty acids from adipose tissue and blocking cholesterol synthesis by binding a key enzyme in the synthesis process.

Target Products:

  • Advicor (Niacin/Lovastatin)
 
HMG CoA Reductase Inhibitors (Statins)
Therapeutics that block cholesterol synthesis by binding a key enzyme in the synthesis process.

Target Products:

  • Pravastatin Sodium
 
Hyperlipidemia  
Free Fatty Acid Inhibitors
Therapeutics that inhibit the release of fatty acids from adipose tissue.

Target Products:

  • Niaspan (Niacin)
 
Free Fatty Acid Inhibitors/HMG CoA Reductase Inhibitors (Statins)
Therapeutics that treat hyperlipidemia by inhibiting the release of free fatty acid from adipose tissues as well as blocking cholesterol synthesis by binding a key enzyme in the synthesis process.

Target Products:

  • Advicor (Niacin/Lovastatin)
 
HMG CoA Reductase Inhibitors (Statins)
Therapeutics that block cholesterol synthesis by binding a key enzyme in the synthesis process.

Target Products:

  • Pravastatin Sodium
 
Parathyroid Gland Disorders  
Hyperparathyroidism (HPT)  
Calcimimetic Agents
Therapeutics that treat hyperparathyroidism by decreasing parathyroid hormone levels, which may provide effective reduction of calcium levels.

Target Products:

  • Cinacalcet Hydrochloride
 
Vitamin D Analogs
Therapeutics that act similar to Vitamin D.

Target Products:

  • Vitamin D Capsule
 
Pituitary Gland Disorders  
Hyperprolactenemia  
Dopamine Receptor Agonists
Products that stimulate the dopamine receptor.

Target Products:

  • Cabergoline
 
Reproductive Disorders  
Amenorrhea  
Progestins
Female sex hormone necessary for the development of the female reproductive system.

Target Products:

  • Medroxyprogesterone
  • Duramed Aygestin (Norethindrone Acetate)
 
Menopause  
Estrogens
Therapeutics that are female sex hormones.

Target Products:

  • Duramed Cenestin (Synthetic Conjugated Estrogens, A)
  • Estradiol
  • Estropipate
  • Duramed Enjuvia (Synthetic Conjugated Estrogens)
 
Estrogens/Progestins
Therapeutics that are mixture of two female sex hormones that are important for the development of the female reproductive system.

Target Products:

  • Duramed Prefest (17-Estradiol/Norgestimate)
  • Nevis (Norethindrone Acetate/Ethinyl Estradiol)
 
Progestins
Therapeutics that are female sex hormones.

Target Products:

  • Medroxyprogesterone
 
Hematology
Hemophilia  
Hemophilia A  
Antidiuretic Agents
Therapeutics that treat prevent the loss of water in the urine.

Target Products:

  • Desmopressin Acetate
 
Phase I/Phase II Clinical Stage Products
Therapeutics that are being investigated for the treatment of hematological disorders in early stages of clinical research where human subject is involved.

Buyer Products:

  • Pharmion Oral Azacitidine
  • CC-11006
  • Revlimid (Lenalidomide)
 
Red Blood Cell (RBC) Disorders  
Anemia  
Folic Acid Derivatives
Therapeutics that treat conditions characterized by reduced delivery of oxygen to body tissues caused by folic acid deficiency.

Target Products:

  • Leucovorin
 
Serum Factor Disorders  
Hypercalcemia  
Osteoclast Bone Resorption Inhibitors
Therapeutics that treat a disorder characterized by excessive calcium levels by inhibiting the resorption of bone.

Target Products:

  • Pamidronate Disodium
 
Hypercholesterolemia  
Free Fatty Acid Inhibitors
Therapeutics that treat the abnormally high concentrations of cholesterol by inhibiting the release of fatty acids from adipose tissue.

Target Products:

  • Niaspan (Niacin)
 
Free Fatty Acid Inhibitors/HMG CoA Reductase Inhibitors (Statins)
Therapeutics that treat the abnormally high concentrations of cholesterol by inhibiting the release of fatty acids from adipose tissue and blocking cholesterol synthesis by binding a key enzyme in the synthesis process.

Target Products:

  • Advicor (Niacin/Lovastatin)
 
HMG CoA Reductase Inhibitors (Statins)
Therapeutics that block cholesterol synthesis by binding a key enzyme in the synthesis process.

Target Products:

  • Pravastatin Sodium
 
Hyperlipidemia  
Free Fatty Acid Inhibitors/HMG CoA Reductase Inhibitors (Statins)
Therapeutics that treat hyperlipidemia by inhibiting the release of free fatty acid from adipose tissues as well as blocking cholesterol synthesis by binding a key enzyme in the synthesis process.

Target Products:

  • Advicor (Niacin/Lovastatin)
 
HMG CoA Reductase Inhibitors (Statins)
Therapeutics that block cholesterol synthesis by binding a key enzyme in the synthesis process.

Target Products:

  • Pravastatin Sodium
 
Hyperuricemia  
Urate Resorption Inhibitors
Therapeutics that prevents the resorption of urate within the kidneys.

Target Products:

  • Sulfinpyrazone
 
Hypokalemia  
Potassium Sparing Diuretic Agents/Thiazide Diuretic Agents
Therapeutics that treat hypokalemia by promoting excretion while inhibiting the removal of potassium.

Target Products:

  • Triamterene/Hydrochlorothiazide
 
Thrombocyte (Platelet) Disorders  
Thrombocythemia  
Megakaryocyte Maturation Inhibitors
Therapeutics that prevents the maturation of platelet producing cells.

Target Products:

  • Anagrelide Hydrochloride
 
White Blood Cell (WBC) Disorders  
Myelodysplastic Syndromes (MDS)  
Antimetabolite Agents  
Pyrimidine Analogs
Therapeutics that treat and manage rmyelodysplastic syndrome by interfering with the production of DNA.

Buyer Products:

  • Pharmion Vidaza (Azacitidine)
 
Immunomodulatory Agents
Therapeutics that treat myelodysplastic syndrome by stimulating the immune system.

Buyer Products:

  • Revlimid (Lenalidomide)
 
Immunology
Autoimmune Disorders  
Arthritis  
Rheumatoid Arthritis (RA)  
Analgesics  
Non-Steroidal Anti-Inflammatory Drugs (NSAID)  
Non-Specific Cyclooxygenase Inhibitors (COX Inhibitors)
Therapeutics that treat pain associated with chronic inflammation of the joints by blocking cyclooxygenase activity.

Target Products:

  • Pliva Diclofenac Sodium
  • Choline Magnesium Trisalicylate
 
Disease Modifying Anti-Rheumatic Drugs (DMARD)  
Dihydrofolate Reductase Inhibitors
Therapeutics that alter or delay the rate of chronic joint inflammation by blocking the action of the dihydrofolate enzyme.

Target Products:

  • Trexall (Methotrexate)
  • Methotrexate Sodium
 
Pyrimidine Synthesis Inhibitors
Therapeutics that alter or delay the rate of chronic joint inflammation by blocking the overproduction of immune cells.

Target Products:

  • Leflunomide
 
Immunotherapy  
Immunosuppressants
Therapeutics that treat chronic inflammation of the joints by inhibiting a full immune response.

Target Products:

  • Pliva Cyclosporine
 
Psoriasis  
Dihydrofolate Reductase Inhibitors
Therapeutics that treat a chronic autoimmune disease characterized by thickened skin with silver scales by blocking the action of the dihydrofolate enzyme.

Target Products:

  • Trexall (Methotrexate)
  • Methotrexate Sodium
 
Immunosuppressants
Therapeutics that treat a chronic autoimmune disease characterized by thickened skin with silver scales by inhibiting a full immune response.

Target Products:

  • Pliva Cyclosporine
 
Immune Deficiency Disorders  
Hereditary Angioedema  
Gonadotropin Inhibitors
Therapeutics that treat swelling under the skin caused by the absence of an essential immune regulator by increasing levels of C4 complement component.

Target Products:

  • Danazol
 
Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS)  
Nucleoside Reverse Transcriptase Inhibitors (NRTI)
Therapeutics that help manage HIV by inhibiting the action of reverse transcriptase, an enzyme necessary for the DNA synthesis on a RNA template.

Target Products:

  • Didanosine Delayed Release
 
Phase I/Phase II Clinical Stage Products
Therapeutics that are being investigated for the treatment of immune disorders in early stages of clinical research where human subject is involved.

Buyer Products:

  • Apremilast/FormerlyCC-10004 (Selective Cytokine Inhibitory Drugs)
  • CC-930 (Janus Kinase Inhibitor)
 
Research/Preclinical Stage Products
Therapeutics that are being investigated for the treatment of immune disorders in very early stages of research where no human subject is involved.

Buyer Products:

  • PDA001 (Human Placenta-derived Stem Cells)
  • CC-15965
  • CC-16057 (Pleiotropic Pathway Modifiers)
  • CC-13097
 
Infectious Diseases
Bacterial
Antibacterial Agents
Broad Spectrum  
Antibiotics  
Macrolides
Therapeutics that treat a wide variety of infections by inhibiting RNA-dependent bacterial protein synthesis.

Target Products:

  • Pliva Azithromycin I.V.
  • Erythromycin
 
Nitroimidazoles
Therapeutics that treat a wide variety of infections by inhibiting bacterial protein synthesis and causing cell death.

Target Products:

  • Pliva Metronidazole
 
Quinolones/Fluoroquinolones
Therapeutics that treat a wide variety of infections by promoting breakage of bacterial DNA strands.

Target Products:

  • Ciprofloxacin
 
Tetracyclines
Therapeutics that treat a wide variety of infections by inhibiting protein synthesis and also causing alterations in cytoplasmic membranes.

Target Products:

  • Demeclocycline Hydrochloride
  • Tetracycline Hydrochloride
 
Narrow Spectrum
Otolaryngology (Ear/Nose/Throat)  
Otitis Media  
Macrolides/Sulfonamides
Therapeutics that treat infection and inflammation of the middle ear space and ear drum by inhibiting RNA-dependent bacterial protein synthesis and by inhibiting folic acid synthesis.

Target Products:

  • E.S.P. (Erythromycin Ethylsuccinate/Sulfisoxazole)
 
Respiratory System  
Pneumonia  
Quinolones/Fluoroquinolones
Therapeutics that treat inflammation of the lungs caused by bacterial infection by bacterial infection by promoting breakage of bacterial DNA strands.

Target Products:

  • Ciprofloxacin
 
Respiratory Tract Infections  
Quinolones/Fluoroquinolones
Therapeutics that treat bacterial infections of the air passage involved in breathing, including the trachea, lungs and bronchi by promoting breakage of bacterial DNA strands.

Target Products:

  • Ciprofloxacin
 
Tuberculosis  
Antitubercular Agents
Therapeutics that treat a bacterial infection of the lung by inhibiting bacterial and mycobacterial RNA synthesis.

Target Products:

  • Ethambutol Hydrochloride
  • Isoniazid
 
Systemic
Leprosy
Erythema Nodosum Leprosum (ENL)
Immunomodulatory Agents
Therapeutics that treat a bacterial infection characterized by the formation of tender, red nodules on the front of the legs by stimulating the immune system.

Buyer Products:

  • Thalomid (Thalidomide)

Target Products:

  • Thalidomide
Urology  
Prostatitis  
Quinolones/Fluoroquinolones
Therapeutics that treat a wide variety of infections by promoting breakage of bacterial DNA strands.

Target Products:

  • Ciprofloxacin
 
Urinary Tract Infections (UTI)  
Antibacterial Agents (Antibiotics)  
Quinolones/Fluoroquinolones
Therapeutics that treat bacterial infections of the urethra, urinary bladder, ureters, and kidneys by promoting breakage of bacterial DNA strands.

Target Products:

  • Ciprofloxacin
 
Mycological (Fungal)  
Antifungal Agents  
Broad Spectrum  
Azoles  
Imidazoles
Therapeutics that treat fungal infections by increasing permeability of the cell wall and causing a toxic build up of hydrogen peroxide.

Target Products:

  • Pliva Ketoconazole
 
Narrow Spectrum  
Dermatology  
Candidiasis  
Polyene Macrolide Antibiotics
Therapeutics that treat fungal infections of the skin caused by yeast by binding to sterols on the fungal cell membrane which results in the loss of potassium and other small molecules from the cell.

Target Products:

  • Pliva Nystatin
 
Onychomycosis (Nail)  
Amine Derivatives  
Allyl
Therapeutics that treat fungal infections of the nail caused by yeast by causing a deficiency in the cell wall.

Target Products:

  • Terbinafine Hydrochloride
 
Digestive System  
Mucous  
Candidiasis  
Polyene Macrolide Antibiotics
Therapeutics that treat fungal infections of the secretory lining of the tissues caused by a yeast by binding to sterols on the fungal cell membrane which results in the loss of potassium and other small molecules from the cell.

Target Products:

  • Pliva Nystatin
 
Nervous System  
Cryptococcal Meningitis  
Triazoles
Therapeutics that treat fungal infections of lining of the brain and the spinal cord by increasing permeability of the cell wall and causing a toxic build up of hydrogen peroxide.

Target Products:

  • Pliva Fluconazole
 
Otolaryngology (Ear/Nose/Throat)  
Esophageal Candidiasis  
Triazoles
Therapeutics that treat fungal infections of the esophagus caused by yeast by increasing permeability of the cell wall and causing a toxic build up of hydrogen peroxide.

Target Products:

  • Pliva Fluconazole
 
Oropharyngeal Candidiasis  
Azoles  
Triazoles
Therapeutics that treat fungal infections of the mouth and pahrynx caused by yeast by increasing permeability of the cell wall and causing a toxic build up of hydrogen peroxide.

Target Products:

  • Pliva Fluconazole
 
Polyene Macrolide Antibiotics
Therapeutics that treat fungal infections of the mucosa caused by yeast by binding to sterols on the fungal cell membrane which results in the loss of potassium and other small molecules from the cell.

Target Products:

  • Pliva Nystatin
 
Urology  
Vaginal Candidiasis  
Azoles  
Triazoles
Therapeutics that treat fungal infections of the female reproductive organ caused by yeast by increasing permeability of the cell wall and causing a toxic build up of hydrogen peroxide.

Target Products:

  • Pliva Fluconazole
 
Protozoal  
Antiprotozoal Agents  
Broad Spectrum  
Nitroimidazoles
Therapeutics that treat infections caused by a wide variety of unicellular organisms by inhibiting protein synthesis and causing cell death.

Target Products:

  • Pliva Metronidazole
 
Narrow Spectrum  
Malaria  
Aminoquinolines
Therapeutics that treat parasitic infections caused by Plasmodia in red blood cells by inhibiting parasite growth.

Target Products:

  • Mefloquine Hydrochloride
 
Viral  
RNA Viruses  
Retrovirus  
Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS)  
Nucleoside Reverse Transcriptase Inhibitors (NRTI)
Therapeutics that help manage HIV by inhibiting the action of reverse transcriptase, an enzyme necessary for the DNA synthesis on a RNA template.

Target Products:

  • Didanosine Delayed Release
 
Vaccines  
Viral  
Single Target  
Adenoviruses
Therapeutics that prevent or treat viral infections which commonly cause upper respiratory infections, such as common cold.

Target Products:

  • Adenovirus Vaccine
 
Musculoskeletal System
Phase I/Phase II Clinical Stage Products
Therapeutics that are being investigated for the treatment of skeletal system disorders in early stages of clinical research where human subject is involved.

Buyer Products:

  • CC-4047 (Immunomodulatory Drug)
  • Apremilast/FormerlyCC-10004 (Selective Cytokine Inhibitory Drugs)
 
Skeletal Disorders  
Bone Disorders  
Osteoporosis  
Hormonal Treatments  
Estrogens
Therapeutics that treat osteoporosis by providing female hormones which results in a decrease in the rate of bone loss due to osteoclasts.

Target Products:

  • Estradiol
  • Estropipate
 
Estrogens/Progestins
Therapeutics that treat osteoporosis by providing female hormones which results in a decrease in the rate of bone loss due to osteoclasts.

Target Products:

  • Nevis (Norethindrone Acetate/Ethinyl Estradiol)
  • Duramed Prefest (17-Estradiol/Norgestimate)
 
Osteoclast Bone Resorption Inhibitors
Therapeutics that treat osteoporosis by preventing loss of bone mass due to osteoclasts.

Target Products:

  • Alendronate Sodium
 
Paget`s Disease  
Osteoclast Bone Resorption Inhibitors
Therapeutics that treat paget's disease by inhibiting the loss of bone material by osteoclasts.

Target Products:

  • Alendronate Sodium
  • Pamidronate Disodium
 
Joint Disorders  
Ankylosing Spondylitis  
Non-Steroidal Anti-Inflammatory Drugs (NSAID)  
Non-Specific Cyclooxygenase Inhibitors (COX Inhibitors)
Therapeutics that treat inflammation by non-specifically inhibiting the action of cyclooxygenase.

Target Products:

  • Pliva Diclofenac Sodium
 
Gouty Arthritis  
Urate Resorption Inhibitors
Therapeutics that treat gouty arthritis by preventing the active reabsorption of urate at the renal tubule thus increasing the excretion of urinary acid and lowering serum concentrations of urate.

Target Products:

  • Sulfinpyrazone
 
Osteoarthritis (OA)  
Non-Steroidal Anti-Inflammatory Drugs (NSAID)  
Non-Specific Cyclooxygenase Inhibitors (COX Inhibitors)
Therapeutics that treat inflammation by non-specifically inhibiting the action of cyclooxygenase.

Target Products:

  • Pliva Diclofenac Sodium
 
Rheumatoid Arthritis (RA)  
Analgesics  
Non-Steroidal Anti-Inflammatory Drugs (NSAID)  
Non-Specific Cyclooxygenase Inhibitors (COX Inhibitors)
Therapeutics that treat pain associated with chronic inflammation of the joints by blocking cyclooxygenase activity.

Target Products:

  • Choline Magnesium Trisalicylate
  • Pliva Diclofenac Sodium
 
Disease Modifying Anti-Rheumatic Drugs (DMARD)  
Dihydrofolate Reductase Inhibitors
Therapeutics that alter or delay the rate of chronic joint inflammation by blocking the action of the dihydrofolate enzyme.

Target Products:

  • Trexall (Methotrexate)
  • Methotrexate Sodium
 
Pyrimidine Synthesis Inhibitors
Therapeutics that alter or delay the rate of chronic joint inflammation by blocking the overproduction of immune cells.

Target Products:

  • Leflunomide
 
Immunotherapy  
Immunosuppressants
Therapeutics that treat rheumatoid arthritis by suppressing the immune system.

Target Products:

  • Pliva Cyclosporine
 
Neurology
Neurological Disorders  
Alzheimer`s Disease  
Acetylcholinesterase Inhibitors/Nicotinic Receptor Modulators
Therapeutics that treat Alzheimer's Disease by preventing the breakdown of a the neurotransmitter, acetylcholine, and by modulating the receptor that binds nicotine.

Target Products:

  • Galantamine Hydrobromide/Galantamine Hydrobromide Extended Release
 
N-Methyl-D-Aspartate (NMDA) Receptor Antagonists
Therapeutics that treat the disorders involving the progressive degeneration and death of brain cells by preventing the actions of an amino acid neurotransmitter, N-Methyl-D-Aspartate.

Target Products:

  • Memantine
 
Epilepsy  
Partial Seizures  
Complex  
Adjunctive Therapy  
Sodium Channel Blocking Agents/Gamma-Aminobutyric Acid (GABA) Receptor Agonists
Therapeutics that treat complex partial seizures by preventing the uptake of gamma-aminobutyric acid as well as blocking the sodium channels which in turn block the conductance of electrical impulses through the brain.

Target Products:

  • Zonisamide
  • Topiramate
 
Monotherapy  
Sodium Channel Blocking Agents/Gamma-Aminobutyric Acid (GABA) Receptor Agonists
Therapeutics that treat complex partial seizures by preventing the uptake of gamma-aminobutyric acid as well as blocking the sodium channels which in turn block the conductance of electrical impulses through the brain.

Target Products:

  • Topiramate
 
Simple  
Adjunctive Therapy  
Sodium Channel Blocking Agents/Gamma-Aminobutyric Acid (GABA) Receptor Agonists
Therapeutics that treat simple partial seizure by both preventing the uptake of gamma-aminobutyric acid which prevents nerve activation as well as blocking the sodium channels which in turn block the conductance of neural impulses.

Target Products:

  • Zonisamide
  • Topiramate
 
Monotherapy  
Sodium Channel Blocking Agents/Gamma-Aminobutyric Acid (GABA) Receptor Agonists
Therapeutics that treat simple partial seizure by both preventing the uptake of gamma-aminobutyric acid which prevents nerve activation as well as blocking the sodium channels which in turn block the conductance of neural impulses.

Target Products:

  • Topiramate
 
Primary Generalized Seizures  
Absence (Petit Mal)  
Adjunctive Therapy  
Gamma-Aminobutyric Acid (GABA) Reuptake Inhibitors
Therapeutics that treat Petit Mal Seizures by preventing the uptake of molecules that prevents nerve activation.

Target Products:

  • Clonazepam ODT
  • Pliva Valproic Acid
 
Monotherapy  
Calcium Channel Blocking Agents
Therapeutics that treat Petit Mal Seizures by preventing the entrance of calcium into nerve cells.

Target Products:

  • Pliva Ethosuximide
  • Ethosuximide
 
Gamma-Aminobutyric Acid (GABA) Reuptake Inhibitors
Therapeutics that treat Petit Mal Seizures by preventing the uptake of molecules that prevents nerve activation.

Target Products:

  • Clonazepam ODT
  • Pliva Valproic Acid
 
Akinetic Pattern  
Adjunctive Therapy  
Gamma-Aminobutyric Acid (GABA) Reuptake Inhibitors
Therapeutics that treat Akinetic Pattern Seizures by preventing the uptake of molecules that prevents nerve activation.

Target Products:

  • Clonazepam ODT
 
Monotherapy  
Gamma-Aminobutyric Acid (GABA) Reuptake Inhibitors
Therapeutics that treat Akinetic Pattern Seizures by preventing the uptake of molecules that prevents nerve activation.

Target Products:

  • Clonazepam ODT
 
Myoclonic  
Adjunctive Therapy  
Gamma-Aminobutyric Acid (GABA) Reuptake Inhibitors
Therapeutics that treat Myoclonic Seizures by inhibiting the uptake of molecules that prevent nerve activation.

Target Products:

  • Clonazepam ODT
 
Monotherapy  
Gamma-Aminobutyric Acid (GABA) Reuptake Inhibitors
Therapeutics that treat Myoclonic Seizures by inhibiting the uptake of molecules that prevents nerve activation.

Target Products:

  • Clonazepam ODT
 
Tonic-Clonic (Grand Mal)  
Sodium Channel Blocking Agents/Gamma-Aminobutyric Acid (GABA) Receptor Agonists
Therapeutics that treat simple partial seizure by both preventing the uptake of gamma-aminobutyric acid which prevents nerve activation as well as blocking the sodium channels which in turn block the conductance of neural impulses.

Target Products:

  • Topiramate
 
Headaches  
Vascular (Migraine)  
Prophylactic Treatments  
Beta Adrenergic Receptor Blocking Agents (Beta Blockers)
Therapeutics that treat Migraine by inhibiting stimulation of beta adrenergic receptors.

Target Products:

  • Pliva Propranolol Hydrochloride
 
Neuromuscular Disorders  
Myasthenia Gravis (MG)  
Cholinesterase Inhibitors
Therapeutics that treat Myasthenia Gravis by maintaining the transmission of nerve impulses by inhibiting the enzyme that breaks down acetylcholine.

Target Products:

  • Pyridostigmine Bromide
 
Parkinson`s Disease (PD)  
Adjunctive Treatments  
Cholinergic Receptor Blocking Agents
Therapeutics that assist in the treatment of the disorder involving nerve cell loss in portions of the brain that leads to uncontrolled tremors, abnormal posture and speech problems by blocking acetylcholine receptors on neurons.

Target Products:

  • Pliva Benztropine Mesylate
 
Monotherapy  
Dopamine Receptor Agonists
Therapeutics that treat the disorder involving nerve cell loss in portions of the brain that leads to uncontrolled tremors, abnormal posture and speech problems by stimulating dopamine receptors on the neurons.

Target Products:

  • Pramipexole Dihydrochloride
 
Psychiatric Disorders
Anxiety  
Generalized Anxiety Disorder (GAD)  
Antihistamines
Therapeutics that treat anxiety by blocking the action of histamines.

Target Products:

  • Pliva Hydroxyzine Hydrochloride
  • Hydroxyzine Pamoate
 
Dopamine Receptor Blocking Agents
Therapeutics that treat anxiety by blocking dopamine receptors.

Target Products:

  • Prochlorperazine Maleate
 
Gamma-Aminobutyric Acid (GABA) Receptor Agonists
Therapeutics that treat anxiety by enhancing the inhibitory neurotransmitter action of gamma-aminobutyric acid.

Target Products:

  • Alprazolam Extended Release
  • Chlordiazepoxide Hydrochloride
  • Diazepam
 
Selective Norepinephrine Reuptake Inhibitors (SNRI)
Therapeutics that treat anxiety by selectively preventing the removal of norepinephrine, and potentiating neurotransmitter activity in the central nervous system (CNS).

Target Products:

  • Pliva Venlafaxine Hydrochloride
 
Obsessive Compulsive Disorder (OCD)  
Selective Serotonin Reuptake Inhibitors (SSRI)
Therapeutics that treat Anxiety by selectively preventing the removal of serotonin.

Target Products:

  • Fluvoxamine Maleate
  • Fluoxetine Hydrochloride
  • Pliva Sertraline Hydrochloride
 
Panic Disorder  
Gamma-Aminobutyric Acid (GABA) Receptor Agonists
Therapeutics that treat panic disorder by enhancing the inhibitory neurotransmitter action of gamma-aminobutyric acid.

Target Products:

  • Clonazepam ODT
  • Alprazolam Extended Release
 
Selective Serotonin Reuptake Inhibitors (SSRI)
Therapeutics that treat panic disorder by selectively preventing the removal of serotonin.

Target Products:

  • Pliva Sertraline Hydrochloride
 
Post-Traumatic Stress Disorder (PTSD)  
Selective Serotonin Reuptake Inhibitors (SSRI)
Therapeutics that treat post traumatic stress disorder by selectively preventing the removal of serotonin.

Target Products:

  • Pliva Sertraline Hydrochloride
 
Social Anxiety Disorder (SAD)  
Selective Norepinephrine Reuptake Inhibitors (SNRI)
Therapeutics that treat Social Anxiety Disorder by selectively preventing the removal of norepinephrine, and potentiating neurotransmitter activity in the central nervous system (CNS).

Target Products:

  • Pliva Venlafaxine Hydrochloride
 
Selective Serotonin Reuptake Inhibitors (SSRI)
Therapeutics that treat Social Anxiety Disorder by selectively preventing the removal of serotonin.

Target Products:

  • Pliva Sertraline Hydrochloride
 
Childhood/Adolescent Disorders
Attention Deficit Disorder (ADD)/Attention Deficit Hyperactivity Disorder (ADHD)
Dopamine Receptor Blocking Agents
Therapeutics that treat attention deficit disorder by blocking the dopamine receptors.

Buyer Products:

  • Ritalin LA (Methylphenidate Hydrochloride)
  • Focalin XR (Refined D-Methylphenidate HCl)
  • Focalin (Refined D-Methylphenidate HCl)

Target Products:

  • Dexmethylphenidate Hydrochloride Extended-Release Capsules
Sympathomimetic Agents
Therapeutic members of the amphetamine group of sympathomimetic amines that treat the disorder involving hyperactivity in children due to an abnormally short attention span.

Target Products:

  • Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate And Amphetamine Sulfate Tablets
  • Duramed Adderall (Dextroamphetamine/Amphetamine)
  • Dextroamphetamine Sulfate Extended Release
 
Enuresis (Bedwetting)  
Antidiuretic Agents
Therapeutics that treat enuresis by suppressing the passing of urine.

Target Products:

  • Desmopressin Acetate
 
Eating Disorders  
Bulimia  
Selective Serotonin Reuptake Inhibitors (SSRI)
Therapeutics that treat eating disorders by selectively preventing the removal of serotonin.

Target Products:

  • Fluoxetine Hydrochloride
 
Mood Disorders  
Bipolar Disorders (Manic Depressive Disorders)  
Lithium-Based Agents
Therapeutics that treat bipolar disorders by decreasing the concentrations of neurotransmitters.

Target Products:

  • Lithium Carbonate Extended Release
 
Monoaminergic Antagonists
Therapeutics that treat bipolar disorder by blocking the serotonin and dopamine receptors.

Target Products:

  • Olanzapine
  • Risperidone
 
Depression  
Selective Norepinephrine Reuptake Inhibitors (SNRI)
Therapeutics that treat depression by selectively preventing the removal of norepinephrine, and potentiating neurotransmitter activity in the central nervous system (CNS).

Target Products:

  • Pliva Venlafaxine Hydrochloride
 
Selective Serotonin Reuptake Inhibitors (SSRI)
Therapeutics that treat depression by selectively preventing the removal of serotonin.

Target Products:

  • Fluoxetine Hydrochloride
  • Pliva Sertraline Hydrochloride
  • Trazodone Hydrochloride
 
Tetracyclic Compounds
Therapeutics that treat depression by increasing the synaptic concentrations of norepinephrine.

Target Products:

  • Mirtazapine
 
Tricyclic Compounds
Therapeutics that treat depression by increasing the synaptic concentrations of norepinephrine and serotonin.

Target Products:

  • Duramed Vivactil (Protriptyline HCl)
  • Duramed Surmontil (Trimipramine Maleate)
 
Premenstrual Dysphoric Disorders  
Selective Serotonin Reuptake Inhibitors (SSRI)
Therapeutics that treat premenstrual dysphoric disorders by selectively preventing the removal of serotonin.

Target Products:

  • Pliva Sertraline Hydrochloride
 
Schizophrenia  
Dopamine Receptor Blocking Agents
Therapeutics that treat schizophrenia by blocking the dopamine receptors.

Target Products:

  • Prochlorperazine Maleate
  • Clozapine
 
Monoaminergic Antagonists
Therapeutics that treat schizophrenia by blocking the serotonin and dopamine receptors.

Target Products:

  • Olanzapine
  • Risperidone
 
Sleep Disorders  
Insomnia  
Gamma-Aminobutyric Acid (GABA) Receptor Agonists
Therapeutics that treat insomnia by enhancing the inhibitory action of gamma-aminobutyric acid.

Target Products:

  • Zolpidem Extended Release
  • Diazepam
 
Narcolepsy  
Alpha Adrenergic Receptor Agonists
Therapeutics that treat narcolepsy by stimulating the adrenergic receptors, which causes nervous system stimulation.

Target Products:

  • Modafinil
 
Sympathomimetic Agents
Therapeutic members of the amphetamine group of sympathomimetic amines that treat the disorder involving hronic and sudden daytime sleepiness.

Target Products:

  • Dextroamphetamine Sulfate Extended Release
 
Obstetrics/Gynecology  
Child Birth/Pregnancy  
Prevention (Contraception)  
Contraceptives (Birth Control)  
Estrogens
Therapeutics that prevent conception by decreasing the secretion of gonadotropin-releasing hormone in the hypothalamus, resulting in an anti-ovulatory effect.

Target Products:

  • Kelnor (Ethynodiol Diacetate/Ethinyl Estradiol)
 
Estrogens/Progestins
Therapeutics that prevent conception by decreasing the secretion of gonadotropin-releasing hormone in the hypothalamus, resulting in an anti-ovulatory effect.

Target Products:

  • Velivet (Desogestrel/Ethinyl Estradiol)
  • Portia (Levonorgestrel/Ethinyl Estradiol)
  • Enpresse (Levonorgestrel/Ethinyl Estradiol)
  • Kariva (Desogestrel/Ethinyl Estradiol)
  • Lessina (Levonorgestrel/Ethinyl Estradiol)
  • Nortrel (Ethinyl Estradiol/Norethindrone) 7/7/7
  • Duramed Seasonale (Levonorgestrel/Ethinyl Estradiol)
  • Sprintec/Tri-Sprintec (Norgestimate/Ethinyl Estradiol)
  • Aviane 28 (Levonorgestrel/Ethinyl Estradiol)
  • Cryselle (Norgestrel/Ethinyl Estradiol)
  • Duramed Nordette Tablets (Levonorgestrel/Ethinyl Estradiol)
  • Seasonique Extended Release (Levonorgestrel/Ethinyl Estradiol)
  • Loestrin Fe (Norethindrone Acetate, Ethinyl Estradiol, Ferrous Fumarate)
  • Junel (Norethindrone Acetate, Ethinyl Estradiol, Ferrous Fumarate)
  • Ocella (Drospirenone/Ethinyl Estradiol)
  • Lo Seasonique (Levonorgestrel/Ethinyl Estradiol)
  • Aranelle (Norethindrone/Ethinyl Estradiol)
  • Mircette (Desogestrel Ethinyl Estradiol)
  • Apri (Desogestrel/Ethinyl Estradiol)
  • Balziva (Norethindrone And Ethinyl Estradiol)
  • Jolessa (Levonorgestrel/Ethinyl Estradiol)
  • Tri-Legest Fe (Norethindrone Acetate And Ethinyl Estradiol Tablets, USP And Ferrous Fumarate tablets
 
Progestins
Contraceptive Therapeutics that are female sex hormone necessary for the development of the female reproductive system

Target Products:

  • Plan B OTC (Levonorgestrel)
  • Norethindrone Acetate
  • Camila (Norethindrone)
  • Plan B Prescription (Levonorgestrel)
  • Errin (Norethindrone)
 
Female Genital Disorders  
Endometriosis  
Gonadotropin Inhibitors
Therapeutics that treat endometriosis by preventing the release of the pituitary gland hormone, gonadotropin.

Target Products:

  • Danazol
 
Ovarian  
Hypogonadism  
Hormonal Treatments  
Estrogens
These are female sex hormones.

Target Products:

  • Estradiol
  • Estropipate
 
Vulvovaginal  
Atrophy  
Hormonal Treatments  
Estrogens
Therapeutics that treat disorders characterized by thinning of the vaginal walls with the female sex hormone estrogen.

Target Products:

  • Estradiol
  • Duramed Cenestin (Synthetic Conjugated Estrogens, A)
  • Estropipate
  • Bijuva Cream (Synthetic Conjugated Estrogens, A)
 
Estrogens/Progestins
Therapeutics that treat disorders characterized by thinning of the vaginal walls with a combination of the female sex hormones estrogen and progestin.

Target Products:

  • Duramed Prefest (17-Estradiol/Norgestimate)
 
Oncology
Breast Cancer  
Localized  
Antimetabolite Agents  
Dihydrofolate Reductase Inhibitors
Therapeutics that treat and manage breast cancers by inhibiting an enzyme needed for the synthesis of DNA.

Target Products:

  • Methotrexate Sodium
  • Trexall (Methotrexate)
 
Estrogen Receptor Blocking Agents
Therapeutics that treat and manage breast cancers by blocking the uptake of estrogen which has been implicated in causing breast cancer.

Target Products:

  • Tamoxifen Citrate
 
Progestins
Therapeutics that treat and manage breast cancers by providing progestins which in turn results in decreased estrogen levels.

Target Products:

  • Megestrol Acetate
 
Metastatic  
Antimicrotubule Agents
Therapeutics that treat and manage cancers of the breast that have spread beyond their original tumor site by blocking the normal function of microtubules, thus inhibiting cell division.

Target Products:

  • Paclitaxel Injection/Pliva Paclitaxel Injection
 
Estrogen Receptor Blocking Agents
Therapeutics that treat and manage breast cancer by blocking the uptake of estrogen which has been implicated in causing breast cancer.

Target Products:

  • Tamoxifen Citrate
 
Dermatology  
Malignant Melanoma  
Ribonucleotide Reductase Inhibitors
Therapeutics that treat and manage cancers of pigment cells in the epidermis and dermis by interfering with DNA synthesis.

Target Products:

  • Hydroxyurea
 
Digestive System  
Colon Cancer/Colorectal Cancer  
Metastatic  
Alkylating Agents  
Platinum-Based Agents
Platinum containing therapeutics that are meant to treat and manage colorectal cancers that have spread beyond their original tumor site by interacting with DNA to inhibit cell division.

Target Products:

  • Oxaliplatin
 
Topoisomerase I Inhibitors
Therapeutics that treat and manage colorectal cancers by inhibiting a specific enzyme needed for transcription and replication of DNA.

Target Products:

  • Pliva Irinotecan Hydrochloride
 
Palliative Agents  
Folic Acid Derivatives
Therapeutics that treat colorectal cancers by helping to reduce toxicity by allowing DNA/RNA/Protein synthesis to occur even when the pathway has been blocked by folic acid antagonists.

Target Products:

  • Leucovorin
 
Endocrinology  
Parathyroid Gland  
Palliative Agents  
Calcimimetic Agents
Therapeutics that treat hypercalcemia (elevated calcium levels in the blood) by decreasing parathyroid hormone levels.

Target Products:

  • Cinacalcet Hydrochloride
 
Head/Neck Cancer  
Localized  
Antimetabolite Agents  
Dihydrofolate Reductase Inhibitors
Therapeutics that treat and manage primary tumors of the head and neck by inhibiting the production of DNA.

Target Products:

  • Methotrexate Sodium
  • Trexall (Methotrexate)
 
Ribonucleotide Reductase Inhibitors
Therapeutics that treat and manage primary tumors of the head and neck by interfering with DNA synthesis.

Target Products:

  • Hydroxyurea
 
Hematology
Leukemia (White Blood Cell Cancer)
Lymphoid
Acute  
Lymphocytic  
Antimetabolite Agents  
Dihydrofolate Reductase Inhibitors
Therapeutics that treat and manage rapidly progressing cancers of lymphocytic cells by inhibiting an enzyme needed for the synthesis of DNA.

Target Products:

  • Methotrexate Sodium
  • Trexall (Methotrexate)
 
Chronic  
Lymphocytic (CLL)  
Immunomodulatory Agents
Therapeutics that treat chronic lymphocytic leukemia by stimulating the immune system.

Buyer Products:

  • Revlimid (Lenalidomide)
 
Meningeal  
Antimetabolite Agents  
Dihydrofolate Reductase Inhibitors
Therapeutics that treat and manage neoplasm's of immature immune cells that have spread to the brain by inhibiting an enzyme needed for the synthesis of DNA.

Target Products:

  • Trexall (Methotrexate)
  • Methotrexate Sodium
 
Myeloid  
Acute  
Promyelocytic (APL)  
Retinoids/Vitamin A Analogs
Therapeutics that treat acute promyelocytic leukemia by helping in cell differentiation as well as decreasing proliferation of cells.

Target Products:

  • Tretinoin Capsule
 
Chronic  
Myelogenous (CML)  
Ribonucleotide Reductase Inhibitors
Therapeutics that treat and manage slowly progressing cancers of myelogenous cells by interfering with DNA synthesis.

Target Products:

  • Hydroxyurea
 
Lymphoma (Lymphatic Cancer)  
Non-Hodgkin`s Lymphoma (NHL)  
Antimetabolite Agents  
Dihydrofolate Reductase Inhibitors
Therapeutics that treat and manage lymphomas of B-cells and T-cells by inhibiting the production of DNA.

Target Products:

  • Methotrexate Sodium
  • Trexall (Methotrexate)
 
Multiple Myeloma (Plasma Cell Cancer)
Immunomodulatory Agents
Therapeutics that treat multiple myeloma by stimulating the immune system.

Buyer Products:

  • Revlimid (Lenalidomide)
  • Thalomid (Thalidomide)

Target Products:

  • Thalidomide
Palliative Agents  
Alkylating Agents  
Nitrogen Mustard Type
Therapeutics derived from mustard gas that treat and manage cancers of mature antibody producing white blood cells by interacting with DNA and inhibiting cell division but are not curative.

Buyer Products:

  • Alkeran (Melphalan Hydrochloride)
 
Musculoskeletal System  
Bone Cancer  
Osteosarcoma  
Palliative Agents  
Folic Acid Derivatives
Therapeutics that are meant to reduce the toxicity of treating malignant tumors of the bone by allowing DNA/RNA/Protein synthesis to occur even when the pathway has been blocked by folic acid antagonists.

Target Products:

  • Leucovorin
 
Metastatic  
Osteolytic Bone Metastases  
Osteoclast Bone Resorption Inhibitors
Therapeutics that treat and manage bone cancers that have spread beyond their original tumor site by preventing the loss of bone mass followed by deposition of new bone which can result in entrapped tumors below the new bone surface.

Target Products:

  • Pamidronate Disodium
 
Phase I/Phase II Clinical Stage Products
Therapeutics that are being investigated for the treatment and management of cancer in early stages of clinical research where human subject is involved.

Buyer Products:

  • CC-4047 (Immunomodulatory Drug)
  • Pharmion Oral Azacitidine
  • ACE-011
  • CC-8490 (Benzopyran)
  • Pharmion Vidaza (Azacitidine)
  • Focalin (Refined D-Methylphenidate HCl)
  • Revlimid (Lenalidomide)
 
Research/Preclinical Stage Products
Therapeutics that are being investigated for the treatment and management of cancer and are currently in an early research or preclinical stage of development.

Buyer Products:

  • CC-113
  • Ligase Inhibitors Program
  • CC-0227113 (Anti-Proliferative Agent)
  • PDA001 (Human Placenta-derived Stem Cells)
 
Respiratory System/Thoracic  
Lung Cancer  
Small Cell Lung Cancer (SCLC)  
Topoisomerase II Inhibitors
Therapeutics that treat and manage cancers of the small cells in the lung by inhibiting a specific enzyme, topoisomerase II, needed for transcription and replication of DNA.

Buyer Products:

  • Pharmion Amrubicin (Anthracycline)
 
Urology
Endometrial Cancer  
Localized  
Progestins
Therapeutics that treat and manage cancer of the endometrial cells lining the uterus by providing a female sex hormone necessary for the development of the female reproductive system.

Target Products:

  • Megestrol Acetate
 
Kidney Cancer (Renal Cell Carcinoma)  
Metastatic  
Hormonal Treatments  
Progestins
Therapeutics that treat and manage renal cancers that have spread beyond their original tumor site by supplying a female sex hormone necessary for the development of the female reproductive system.

Target Products:

  • Megestrol Acetate
 
Ovarian Cancer
Adenocarcinoma
Alkylating Agents
Nitrogen Mustard Type
Therapeutics derived from mustard gas that treat and manage cancer of cells lining the ovary by interacting with DNA and inhibiting cell division.

Buyer Products:

  • Alkeran (Melphalan Hydrochloride)
 
Platinum-Based Agents
Platinum containing therapeutics that treat and manage cancer of cells lining the ovary by interacting with DNA and inhibiting cell division.

Target Products:

  • Carboplatin
 
Ribonucleotide Reductase Inhibitors
Therapeutics that treat and manage cancer of cells lining the ovary by interfering with DNA synthesis.

Target Products:

  • Hydroxyurea
 
Palliative Agents  
Alkylating Agents  
Platinum-Based Agents
Platinum containing therapeutics that treat and manage ovarian cancers by interacting with DNA and inhibiting cell division but are not curative.

Target Products:

  • Carboplatin
 
Prostate Cancer  
Localized  
Androgen Receptor Blockers
Therapeutics that treat prostate cancer by blocking androgen receptors. This limits the action of male hormones which have been implicated as a causative agent in prostate cancer.

Target Products:

  • CyPat (Cyproterone)
 
Metastatic  
Androgen Receptor Blockers
Therapeutics that treat and manage prostate cancers that have spread beyond their original tumor site by binding to the androgen receptors in target tissue thus inhibiting the action of androgens.

Target Products:

  • Flutamide
 
Ophthalmology  
Degenerative Disorders  
Glaucoma  
Carbonic Anhydrase Inhibitors
Therapeutics that decrease the formation of the fluid of the eye.

Target Products:

  • Duramed Diamox (Acetazolamide)
 
Irritation/Inflammation  
Non-Steroidal Anti-Inflammatory Drugs (NSAID)  
Non-Specific Cyclooxygenase Inhibitors (COX Inhibitors)
Therapeutics that counteract or suppress inflammation by non-specifically inhibiting the action of cyclooxygenase.

Target Products:

  • Pliva Ketorolac Tromethamine
 
Pain Management  
Anesthesia  
General (Systemic)  
Adjunctive  
Gamma-Aminobutyric Acid (GABA) Receptor Agonists
Therapeutics that result in anesthesia by enhancing the inhibitory neurotransmitter action of gamma-aminobutyric acid.

Target Products:

  • Diazepam
 
Opioids
Therapeutics that treat pain by binding to certain nervous system receptors which alters both the perception of pain as well as the emotional response to pain.

Target Products:

  • Morphine Sulfate
 
Narcotics  
Analgesics/Opioids
Therapeutics that treat pain by binding to certain nervous system receptors which alters the both the perception of pain as well as the emotional response to pain.

Target Products:

  • Propoxyphene Napsylate and Acetaminophen
  • Oxycodone/Acetaminophen
  • Acetaminophen/Codeine
  • Oxycodone/Ibuprofen
 
Opioid Analgesics
Therapeutics that treat pain by providing the body with a milder opioid substitute.

Target Products:

  • Nalbuphine Hydrochloride
 
Opioids
Therapeutics that treat pain by binding to certain nervous system receptors which alter both the perception of pain as well as the emotional response to pain.

Target Products:

  • Meperidine Hydrochloride
  • Hydromorphone Hydrochloride
  • Pliva Tramadol Hydrochloride
  • Oral Transmucosal Fentanyl Citrate [C-II]
 
Non-Narcotics  
Non-Steroidal Anti-Inflammatory Drugs (NSAID)  
Non-Specific Cyclooxygenase Inhibitors (COX Inhibitors)
Therapeutics that treat pain by non-specifically inhibiting the action of cyclooxygenase.

Target Products:

  • Pliva Diclofenac Sodium
  • Pliva Naproxen Sodium
 
Skeletal Muscle Relaxing Agents
Therapeutics that treat pain by depressing specific synaptic reflexes preferentially.

Target Products:

  • Pliva Cyclobenzaprine HCL
  • Chlorzoxazone
 
Respiratory System  
Lower Respiratory Tract Disorders (Lung Disorders)  
Asthma  
Prophylactic Treatments  
Phosphodiesterase Inhibitors (PDE Inhibitors)
Therapeutics that inhibit the break down of phosphodiesters thereby increasing levels of Nitric Oxide which help in relaxing smooth muscles in the lungs.

Target Products:

  • Pliva Theophylline
 
Bronchitis  
Prophylactic Treatments  
Phosphodiesterase Inhibitors (PDE Inhibitors)
Therapeutics that inhibit the break down of phosphodiesters thereby increasing levels of Nitric Oxide which help in relaxing smooth muscles in the lungs.

Target Products:

  • Pliva Theophylline
 
Emphysema  
Prophylactic Treatments  
Phosphodiesterase Inhibitors (PDE Inhibitors)
Therapeutics that inhibit the break down of phosphodiesters thereby increasing levels of Nitric Oxide which help in relaxing smooth muscles in the lungs.

Target Products:

  • Pliva Theophylline
 
Upper Respiratory Tract Disorders  
Coughs/Colds  
Antihistamines
Therapeutics that inhibit the inflammation by blocking the action of histamines on tissues.

Target Products:

  • Levocetirizine Dihydrochloride
  • Diphenhydramine Hydrochloride
  • Fexofenadine Hydrochloride (12 Hours Extended Release)
 
Antihistamines/Antiserotonins
Therapeutics that inhibit inflammation by blocking the action of histamines and serotonins on tissues.

Target Products:

  • Pliva Cyproheptadine HCl
 
Antitussives
Therapeutics that relieve or prevent coughs.

Target Products:

  • Pliva Benzonatate
 
Steroidal Anti-Inflammatory Drugs (SAID)
Therapeutics that counteract or suppress the inflammation in the upper respiratory tract with steroidal compounds.

Target Products:

  • Triamcinolone Acetonide Nasal Spray
 
Surgery
Cardiovascular System  
Thrombosis  
Thrombin Inhibitors
Therapeutics that thin the blood of a blocked blood vessel during surgery by blocking an enzyme involved in the clotting process.

Target Products:

  • Warfarin Sodium
 
General  
Complications  
Nausea/Vomiting  
Serotonin Receptor Antagonists
Therapeutics that prevent or treat post surgical nausea and vomiting by blocking the receptors that bind serotonin, a neurotransmitter.

Target Products:

  • Ondansetron Hydrochloride
 
Musculoskeletal System
Deep Vein Thrombosis (DVT)
Anticoagulating Agents (Anticoagulants)
Thrombin Inhibitors
Therapeutics that treat vascular obstructions due to platelets and cell matter by blocking an enzyme involved in the clotting process.

Buyer Products:

  • Pharmion Innohep (Tinzaparin Sodium)

Target Products:

  • Warfarin Sodium
Ophthalmology  
Ocular Inflammation  
Non-Steroidal Anti-Inflammatory Drugs (NSAID)  
Non-Specific Cyclooxygenase Inhibitors (COX Inhibitors)
Therapeutics that counteract or suppress inflammation resulting from surgical procedures to remove cataracts by preventing cyclooxygenase activity.

Target Products:

  • Pliva Ketorolac Tromethamine
 
Research/Preclinical Stage Products
Therapeutics that are being investigated for the treatment of surgical complications in very early stages of research where no human subject is involved.

Buyer Products:

  • JNK 359 (Janus Kinase Inhibitor)
 
Toxicology  
Heavy Metal Poisoning  
Chelating Agents  
Iron
Therapeutics that form chemical complexes with iron and are subsequently excreted.

Target Products:

  • Deferoxamine Mesylate
 
Substance Abuse  
Withdrawal  
Alcohol  
Gamma-Aminobutyric Acid (GABA) Receptor Agonists
Therapeutics that treat alcohol withdrawal by increasing the effect of GABA at the relevant neuroreceptors.

Target Products:

  • Diazepam
  • Chlordiazepoxide Hydrochloride
 
Opioid Antagonists
Therapeutics that treat alcohol dependence by blocking the effect of opioids.

Target Products:

  • Naltrexone Hydrochloride
  • Duramed ReVia (Naltrexone Hydrochloride)
 
Narcotics  
Opioid Antagonists
Therapeutics that treat narcotic addiction by blocking the effect of opioids.

Target Products:

  • Naltrexone Hydrochloride
  • Duramed ReVia (Naltrexone Hydrochloride)
 
Transplantation  
Heart  
Rejection Prophylaxis  
Immunosuppressants
Therapeutics that help manage and suppress the response of the immune system to foreign tissue.

Target Products:

  • Pliva Cyclosporine
 
Hepatic (Liver)  
Rejection Prophylaxis  
Immunosuppressants
Therapeutics that manage and suppress the response of the immune system to foreign tissue.

Target Products:

  • Pliva Cyclosporine
 
Renal (Kidney)  
Rejection Prophylaxis  
Immunosuppressants
Therapeutics that manage and suppress the response of the immune system to foreign tissue.

Target Products:

  • Pliva Cyclosporine
 
Urology  
Male Genital Disorders  
Prostate  
Benign Prostate Hyperplasia (BPH)  
5-Alpha Reductase Inhibitors
Therapeutics that inhibit the transformation of testosterone into dihydrotestosterone (DHT), a substance that causes enlargement of the prostate.

Target Products:

  • Finasteride
 
Alpha Adrenergic Receptor Blocking Agents (Alpha Blockers)
Therapeutics that increase blood flow by acting on the alpha adrenergic receptors thus causing the smooth muscle in the prostate to relax and decreasing the constriction on the urinary tract.

Target Products:

  • Pliva Doxazosin Mesylate
  • Alfuzosin HCl Extended-Release
 
Urological Disorders  
Bladder  
Neurogenic Bladder Disease  
Anticholinergic Agents
Therapeutics that block the actions of choline and other cholinergic agents.

Target Products:

  • Pliva Oxybutynin Chloride
 
Cholinergic Agents
Therapeutics that treat bladder dysfunction arising from the malfunction of autonomic nerves that control bladder function with choleinergic agents.

Target Products:

  • Duramed Urecholine (Bethanechol Chloride)
  • Pliva Bethanechol Chloride
 
Urinary Frequency/Urge Incontinence  
Anticholinergic Agents
Therapeutics that treat the inability to control urinary excretory functions by blocking the actions of choline and other cholinergic agents.

Target Products:

  • Pliva Oxybutynin Chloride
  • Oxybutynin Hydrochloride Transdermal Patch
 
Kidney (Renal)  
Chronic Renal Failure (CRF)  
Complications  
Edema  
Loop Diuretic Agents
Therapeutics that treat the accumulation of abnormally large amounts of fluid in subcutaneous tissues by promoting the excretion of urine.

Target Products:

  • Torsemide
 
Potassium Sparing Diuretic Agents/Thiazide Diuretic Agents
Therapeutics that treat the accumulation of abnormally large amounts of fluid in subcutaneous tissue by increasing the excretion of sodium and water, but not potassium in urine.

Target Products:

  • Triamterene/Hydrochlorothiazide
 
Hyperparathyroidism  
Calcimimetic Agents
Therapeutics that treat hyperparathyroidism by decreasing parathyroid hormone levels, which may provide effective reduction of calcium levels.

Target Products:

  • Cinacalcet Hydrochloride
 
Weight Management  
Anorexia (Appetite Loss)  
Progestins
Therapeutics that treat weight loss and other conditions arising from the uncontrolled loss of appetite by administration of hormone progestins.

Target Products:

  • Megestrol Acetate
 
Cachexia  
Anabolic Testosterone Analogs
Therapeutics containing a class of compounds that boost the body's metabolism and help in gaining weight.

Target Products:

  • Oxandrolone
 
Progestins
Therapeutics that treat cachexia by providing female hormones.

Target Products:

  • Megestrol Acetate
 
Healthcare Services  
Support Services  
Biological Specimen Storage
Services providing storage and maintenance for biological products such as donated blood, bone marrows and stem cells.

Buyer Products:

  • LifebankUSA Placental And Cord Blood Stem Cell Bank
 
Medical Devices
Cardiology  
Surgical  
General Procedure  
Grafts  
Patches  
Allograft
A graft made of tissue harvested from another human being.

Buyer Products:

  • Biovance
  • Acelagraft Human Amnioyic Membrane Allograft
 
Clinical Diagnostics  
Chemistry  
Point of Care Testing  
Kits  
Fertility/Reproduction
Test kits used to aid in the assessment of fertility or reproduction.

Target Products:

  • Duramed AmniScreen Home Detection Liner Kit
 
General Surgery  
Invasive  
Transplantation  
Organ Preservation
Devices used to preserve organs prior to transplantation.

Target Products:

  • ViaSpan (Belzer UW)
 
Obstetrics/Gynecology  
Treatment  
Procedure Specific  
Contraception  
Intrauterine Devices (IUD)
IUDs, or Intrauterine devices, are a form of birth control used by women.

Target Products:

  • ParaGard T 380A
 
Transfusion Medicine  
Stem Cell Therapy
Autologous stem cells that are harvested from the patient's own body and implant back into the patients for repair and healing.

Buyer Products:

  • Human Placental Derived Stem Cells (HPDSC)
 

- Focused. Denotes that the company is considered focused in this area. In general, Focused Companies draw the majority of their earnings in the sector/product area specified.

- Sector Pure-Plays. Denotes that the company is focused in the selected sector and generates nearly all earnings in the sector/product area specified.

- Sector Participation. Denotes that the company develops products in this line of business.

Relationship Details

Key Competitors

  Name Dir Percent Market Cap. P/E Ratio (TTM) Fwd P/E P/R Ratio (TTM) Fwd P/Rev Price To Tang. Book Value
Overlap
  Johnson & Johnson n/a 163,255.583 12.95 13.02 2.53 2.54 9.51
Novartis AG (ADR) n/a 105,743.516 13.99 12.66 2.49 2.59 3.59
Amgen, Inc. n/a 61,272.101 15.05 13.01 4.09 4.08 11.35
Shire Plc. (ADR) n/a 8,361.200 36.87 11.40 2.80 2.70 n/a
Buyer
  Johnson & Johnson n/a 163,255.583 12.95 13.02 2.53 2.54 9.51
Roche Holding Ltd. (ADR) n/a 123,605.205 14.77 14.95 3.15 2.96 5.39
Target
  Johnson & Johnson n/a 163,255.583 12.95 13.02 2.53 2.54 9.51
Novartis AG (ADR) n/a 105,743.516 13.99 12.66 2.49 2.59 3.59
Amgen, Inc. n/a 61,272.101 15.05 13.01 4.09 4.08 11.35
Wyeth n/a 49,491.370 11.06 10.54 2.13 2.13 3.31
Bayer AG (ADR) n/a 42,069.377 5.82 10.94 0.92 1.07 n/a
Teva Pharmaceutical Industries Ltd (ADR) n/a 35,520.479 18.76 15.72 3.28 3.24 7.94
Shire Plc. (ADR) n/a 8,361.200 36.87 11.40 2.80 2.70 n/a
Cephalon, Inc. n/a 5,304.534 20.79 16.71 2.81 2.72 15.26
Warner Chilcott Ltd. n/a 3,505.885 27.60 10.18 3.80 3.88 n/a
Perrigo Company n/a 3,054.120 21.86 17.04 1.59 1.44 4.91
Mylan Inc. n/a 2,940.369 n/a 14.86 0.58 0.63 n/a
Watson Pharmaceuticals, Inc. n/a 2,551.389 11.58 12.22 1.01 1.01 4.00
Dr. Reddy's Laboratories Limited (ADR) n/a 1,728.957 19.76 13.97 1.56 1.20 n/a
Alkermes, Inc. n/a 936.943 5.15 7.05 3.90 4.27 2.76
Par Pharmaceutical Companies, Inc. n/a 428.120 n/a 102.58 0.75 0.75 1.33
Momenta Pharmaceuticals, Inc. n/a 415.745 n/a -6.77 19.22 26.66 4.71
Albany Molecular Research, Inc. n/a 327.612 19.77 17.88 1.49 1.41 1.13
Taro Pharmaceutical Industries Ltd. n/a 291.646 13.80 n/a 0.93 n/a 1.42
Noven Pharmaceuticals, Inc. n/a 281.835 21.11 15.25 2.97 2.67 2.89

- Defined by the Company - Defined by Others

Dependent Suppliers

  Name Dir Percent Market Cap. P/E Ratio (TTM) Fwd P/E P/R Ratio (TTM) Fwd P/Rev Price To Tang. Book Value
Buyer
  GPC Biotech AG (ADR) 89.00% 49.361 n/a n/a 2.66 n/a 1.36
Array BioPharma Inc. 14.90% 182.261 n/a -1.47 6.52 7.63 22.65
GlaxoSmithKline plc (ADR) n/a 95,323.292 13.21 10.64 2.64 2.40 80.37
Siegfried Ltd. n/a n/a n/a n/a n/a n/a n/a
Royalty Pharma AG n/a n/a n/a n/a n/a n/a n/a
The Rockefeller University n/a n/a n/a n/a n/a n/a n/a
Johnson Matthey plc n/a n/a n/a n/a n/a n/a n/a
Children's Medical Center Corporation n/a n/a n/a n/a n/a n/a n/a
Target
  Bayer AG (ADR) n/a 42,069.377 5.82 10.94 0.92 1.07 n/a
Teva Pharmaceutical Industries Ltd (ADR) n/a 35,520.479 18.76 15.72 3.28 3.24 7.94
Cephalon, Inc. n/a 5,304.534 20.79 16.71 2.81 2.72 15.26
Watson Pharmaceuticals, Inc. n/a 2,551.389 11.58 12.22 1.01 1.01 4.00
Mack-Cali Realty Corp. n/a 1,515.880 21.14 5.77 1.91 1.92 0.96
Savient Pharmaceuticals, Inc. n/a 246.369 n/a -3.05 62.01 96.57 2.82
Indevus Pharmaceuticals n/a 220.388 n/a -4.77 2.83 2.56 n/a

- Defined by the Company - Defined by Others

Key Customers

  Name Dir Percent Market Cap. P/E Ratio (TTM) Fwd P/E P/R Ratio (TTM) Fwd P/Rev Price To Tang. Book Value
Overlap
  Cardinal Health, Inc. 14.20% 11,964.304 9.59 8.77 0.13 0.12 7.24
McKesson Corporation 14.00% 10,362.063 9.68 9.38 0.10 0.10 3.96
CVS Caremark Corporation 10.40% 38,720.709 12.65 11.22 0.45 0.45 n/a
AmerisourceBergen Corp. 9.50% 5,373.927 21.45 10.89 0.08 0.08 n/a
Buyer
  Cardinal Health, Inc. 14.20% 11,964.304 9.59 8.77 0.13 0.12 7.24
McKesson Corporation 14.00% 10,362.063 9.68 9.38 0.10 0.10 3.96
CVS Caremark Corporation 10.40% 38,720.709 12.65 11.22 0.45 0.45 n/a
AmerisourceBergen Corp. 9.50% 5,373.927 21.45 10.89 0.08 0.08 n/a
Novartis AG (ADR) n/a 105,743.516 13.99 12.66 2.49 2.59 3.59
EntreMed, Inc. n/a 16.835 n/a -0.70 2.28 n/a 2.07
Target
  McKesson Corporation 32.00% 10,362.063 9.68 9.38 0.10 0.10 3.96
Cardinal Health, Inc. 25.00% 11,964.304 9.59 8.77 0.13 0.12 7.24
Abbott Laboratories n/a 81,101.193 17.83 15.66 2.82 2.72 27.66
CVS Caremark Corporation n/a 38,720.709 12.65 11.22 0.45 0.45 n/a
Teva Pharmaceutical Industries Ltd (ADR) n/a 35,520.479 18.76 15.72 3.28 3.24 7.94
Walgreen Company n/a 25,793.923 11.96 11.44 0.44 0.40 2.26
Shire Plc. (ADR) n/a 8,361.200 36.87 11.40 2.80 2.70 n/a
AmerisourceBergen Corp. n/a 5,373.927 21.45 10.89 0.08 0.08 n/a
Cephalon, Inc. n/a 5,304.534 20.79 16.71 2.81 2.72 15.26
Warner Chilcott Ltd. n/a 3,505.885 27.60 10.18 3.80 3.88 n/a
Government - United States n/a n/a n/a n/a n/a n/a n/a

- Defined by the Company - Defined by Others

Key Partners

  Name Dir Percent Market Cap. P/E Ratio (TTM) Fwd P/E P/R Ratio (TTM) Fwd P/Rev Price To Tang. Book Value
Buyer
  Novartis AG (ADR) n/a 105,743.516 13.99 12.66 2.49 2.59 3.59
GlaxoSmithKline plc (ADR) n/a 95,323.292 13.21 10.64 2.64 2.40 80.37
Sharp Corporation (ADR) n/a 7,087.059 7.66 43.07 0.20 0.21 0.58
Array BioPharma Inc. n/a 182.261 n/a -1.47 6.52 7.63 22.65
Pharmacopeia, Inc. n/a 51.064 n/a -1.06 2.22 1.84 n/a
EntreMed, Inc. n/a 16.835 n/a -0.70 2.28 n/a 2.07
PTC Therapeutics, Inc. n/a n/a n/a n/a n/a n/a n/a
Institute of Drug Technology Australia Limited n/a n/a n/a n/a n/a n/a n/a
Evotec AG (ADR) n/a n/a n/a n/a n/a n/a n/a
Siegfried Ltd. n/a n/a n/a n/a n/a n/a n/a
Royalty Pharma AG n/a n/a n/a n/a n/a n/a n/a
Children's Medical Center Corporation n/a n/a n/a n/a n/a n/a n/a
Mikart, Inc. n/a n/a n/a n/a n/a n/a n/a
Penn Pharmaceuticals Ltd. n/a n/a n/a n/a n/a n/a n/a
Johnson Matthey plc n/a n/a n/a n/a n/a n/a n/a
The Rockefeller University n/a n/a n/a n/a n/a n/a n/a
Target
  Abbott Laboratories n/a 81,101.193 17.83 15.66 2.82 2.72 27.66
Bayer AG (ADR) n/a 42,069.377 5.82 10.94 0.92 1.07 n/a
Teva Pharmaceutical Industries Ltd (ADR) n/a 35,520.479 18.76 15.72 3.28 3.24 7.94
Shire Plc. (ADR) n/a 8,361.200 36.87 11.40 2.80 2.70 n/a
Cephalon, Inc. n/a 5,304.534 20.79 16.71 2.81 2.72 15.26
Warner Chilcott Ltd. n/a 3,505.885 27.60 10.18 3.80 3.88 n/a
Watson Pharmaceuticals, Inc. n/a 2,551.389 11.58 12.22 1.01 1.01 4.00
Savient Pharmaceuticals, Inc. n/a 246.369 n/a -3.05 62.01 96.57 2.82
Indevus Pharmaceuticals n/a 220.388 n/a -4.77 2.83 2.56 n/a

- Defined by the Company - Defined by Others

Financials

  Buyer Target Combined Entity
Income Statement
Operating Items
Revenue 2,041.1 2,563.4 4,604.5
Other Revenue 0.0 229.3 229.3
Total Revenue 2,041.1 2,792.7 4,833.8
Cost of Revenue 235.9 1,296.4 1,532.3
SG&A Expense 618.5 855.6 1,474.1
Depreciation & Amortization 77.8 0.0 77.8
Research & Development 561.2 275.6 836.8
Interest Expense 0.0 0.0 0.0
Other Operating Expense 0.0 0.0 0.0
Unusual Expense (Income) 1,740.0 0.0 1,740.0
Total Expenses 3,233.4 2,427.7 5,661.1
Operating Income -1,192.3 365.0 -827.3
Non Operating Items
Interest Expense (Inc.), Net Non-Oprtng 101.6 -98.2 3.4
Other, Net 4.0 -10.0 -6.0
Income Before Taxes -1,103.8 256.8 -847.0
Income Taxes 205.3 105.8 311.2
Income After Taxes -1,309.1 151.0 -1,158.1
Minority Interest (IS) 0.0 1.5 1.5
Net Income - Excl. Xord. Items -1,309.1 152.5 -1,156.6
Discontinued Operations 0.0 -8.9 -8.9
Net Income - Incl. Xord. Items -1,309.1 143.5 -1,165.6
Income Avail. to Common -1,309.1 143.5 -1,165.6
Share Items
Basic Avg. Shares Outstanding 456.5 109.0 565.5
Basic EPS - Excl. Xord. Items n/a 1.40 -2.05
Basic EPS - Incl. Xord. Items n/a 1.32 -2.06
Full Dilution Adjustment 0.0 0.0 0.0
Fully Diluted Shares Outstanding 468.9 111.0 579.9
F.D. EPS - Excl. Xord. Items n/a 1.37 -1.99
F.D. EPS - Incl. Xord. Items n/a 1.29 -2.01
Balance Sheet
Assets
Cash and Equivalents 1,517.1 587.0 2,104.1
ST Investments 937.0 15.0 952.0
Accounts Receivable 275.4 685.0 960.4
Inventory 90.3 431.0 521.3
Prepayments and Advances 0.0 88.0 88.0
Other Current Assets 204.3 62.0 266.3
Current Assets 3,024.2 1,868.0 4,892.2
Accum D&A 0.0 0.0 0.0
PPE, Net 234.4 1,088.0 1,322.4
Goodwill & Intangibles 985.9 1,646.0 2,631.9
Long Term Investments 18.2 19.0 37.2
Other Assets 0.0 0.0 0.0
Other LT Assets 94.7 148.0 242.7
Total Assets 4,357.4 4,769.0 9,126.4
Liabilities
Accounts Payable 54.9 156.0 210.9
Payable/Accrued 0.0 0.0 0.0
Accrued Expenses 329.7 304.0 633.7
ST Debt 0.0 0.0 0.0
Curr Port of LTD & Cap Lease Oblg 0.0 231.0 231.0
Other (Current) Liabilities 64.4 17.0 81.4
Current Liab. 449.0 708.0 1,157.0
LT Debt 0.0 1,715.0 1,715.0
Total LT Debt 0.0 1,715.0 1,715.0
Minority Interest (BS) 0.0 28.0 28.0
Deferred Taxes 0.0 161.0 161.0
Other LT Liab. 320.1 88.0 408.1
Total Liabilities 769.1 2,700.0 3,469.1
Shareholders Equity
Common Stock 4.6 1.0 5.6
Additional Paid in Capital 5,035.2 772.0 5,807.2
Retained Earnings -1,259.7 1,117.0 -142.7
Treasure Stock -153.8 -101.0 -254.8
Other Equity -37.9 280.0 242.1
Total Equity 3,588.4 2,069.0 5,657.4
Total Liab. & Equity 4,357.4 4,769.0 9,126.4
Shares Outstanding 458.1 109.4 567.6
Cash Flow
Operating Cash Flow
CF Net Income 332.0 143.4 475.4
CF Depreciation 34.1 319.8 353.9
CF Amortization 61.1 0.0 61.1
CF Deferred Taxes -15.1 -60.4 -75.6
Other Non-Cash Items 104.0 -5.9 98.1
Change in Working Capital 63.2 -24.7 38.6
Total Cash From Operating Activities 579.4 375.2 954.5
Investing Cash Flow (not calculated)
Capital Expenditures -46.3 -131.4 -177.6
Other Investing Cash Flows 112.8 277.6 390.5
Total Cash From Investing Activities 66.5 146.3 212.8
Financing Cash Flow (not calculated)
Dividends Paid 0.0 0.0 0.0
Purchase Or Sale of Stock 92.4 62.1 154.5
Purchase and Retirement of Debt 0.0 -222.1 -222.1
Other Financing Cash Flow 77.5 8.4 85.9
Total Cash From Financing Activities 169.9 -151.5 18.4
Exchange Rate Effects -59.2 5.6 -53.7
Net Change in Cash 756.5 375.5 1,132.0
Cash Taxes Paid 27.6 88.6 116.1
Cash Interest Paid 2.0 179.5 181.5